Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.49 |
| ▸ | SCN9A | Q15858 | 4/20 | 0.49 |
| ▸ | SCN5A | Q14524 | 3/20 | 0.49 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.48 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.48 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.47 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.47 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.47 |
| ▸ | BRAF | P15056 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | DRD1 | P21728 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.45 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.45 |
| ▸ | PHGDH | O43175 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | SRC | P12931 | 1/20 | 0.44 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.44 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7031232 | 1.00 | MEN1 (0.55) | MEN1KMT2AKCNH2SCN9ASCN5A | |
| SCHEMBL4788895 | 0.93 | KCNH2 (0.49) | MEN1KMT2AKCNH2SCN9ASCN5A | |
| SCHEMBL6820338 | 0.91 | KCNH2 (0.55) | MEN1KMT2AKCNH2SCN9ASCN5A | |
| SCHEMBL7025761 | 0.91 | KCNH2 (0.55) | MEN1KMT2AKCNH2SCN9ASCN5A | |
| SCHEMBL6820334 | 0.91 | KCNH2 (0.55) | MEN1KMT2AKCNH2SCN9ASCN5A | |
| SCHEMBL7026344 | 0.86 | MTNR1A (0.52) | KCNH2SCN9ASCN5AMTNR1AMTNR1B | |
| SCHEMBL7026340 | 0.86 | MTNR1A (0.52) | KCNH2SCN9ASCN5AMTNR1AMTNR1B | |
| SCHEMBL4789479 | 0.86 | LCK (0.46) | MEN1KMT2AKCNH2SCN9ASCN5A | |
| SCHEMBL4789251 | 0.86 | KCNH2 (0.45) | MEN1KMT2AKCNH2SCN9ASCN5A | |
| SCHEMBL4789031 | 0.86 | KCNH2 (0.47) | MEN1KMT2AKCNH2SCN9ASCN5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002022738-A9 | SPECIES MODIFICATION IN MACROCYCLIC POLYESTER OLIGOMERS, AND COMPOSITIONS PREPARED THEREBY | CYCLICS CORP (US) | 2003-03-27 | — | — | WO | disclosed |
| EP-0888319-B1 | SUBSTITUTED 1,2,3,4-TETRAHYDRONAPHTHALENE DERIVATIVES | ASTRAZENECA AB (SE) | 2003-01-29 | — | — | EP | disclosed |
| US-6410530-B1 | CENTRAL NERVOUS SYSTEM DISORDERS; PSYCHOLOGICAL DISORDERS | ASTRAZENECA AB (SE) | 2002-06-25 | — | — | US | disclosed |
| US-6124283-A | Substituted 1,2,3,4-tetrahydronaphthalene derivatives | ASTRA AKTIEBOLAG (SE) | 2000-09-26 | — | — | US | disclosed |