Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.39 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.39 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.35 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.33 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | AHR | P35869 | 1/20 | 0.33 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10098236 | 0.74 | MEN1 (0.43) | MEN1KMT2ANPC1MAPK13MAPK12 | |
| SCHEMBL859294 | 0.68 | NPC1 (0.41) | MEN1KMT2ANPC1MAPK13MAPK12 | |
| Trifluoroacetic Acid SCHEMBL526603 | 0.67 | NPC1 (0.71) | NPC1MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL5331013 | 0.65 | MAPT (0.46) | MEN1KMT2ANPC1MAPK13MAPK12 | |
| SCHEMBL29789709 | 0.65 | MAPT (0.46) | MEN1KMT2ANPC1MAPK13MAPK12 | |
| SCHEMBL30542598 | 0.65 | MEN1 (0.44) | MEN1KMT2ANPC1MAPK13MAPK12 | |
| SCHEMBL26613492 | 0.65 | ALDH1A1 (0.47) | MEN1KMT2ANPC1MAPK13MAPK12 | |
| SCHEMBL26613377 | 0.65 | MEN1 (0.44) | MEN1KMT2ANPC1MAPK13MAPK12 | |
| Trifluoroacetic Acid SCHEMBL527380 | 0.65 | MAPT (0.73) | NPC1MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL29746291 | 0.64 | MAPT (0.38) | MEN1KMT2ANPC1MAPK13MAPK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1274700-A1 | DIHYDROBENZOPYRANS, DIHYDROBENZOTHIOPYRANS, AND TETRAHYDROQUINOLINES FOR THE TREATMENT OF COX-2-MEDIATED DISORDERS | Pharmacia Corporation (US) | 2003-01-15 | — | — | EP | disclosed |
| WO-2001049675-A1 | DIHYDROBENZOPYRANS, DIHYDROBENZOTHIOPYRANS, AND TETRAHYDROQUINOLINES FOR THE TREATMENT OF COX-2-MEDIATED DISORDERS | PHARMACIA CORPORATION (US) | 2001-07-12 | — | — | WO | disclosed |