Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 7/20 | 0.62 |
| ▸ | LMNA | P02545 | 3/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.62 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.62 |
| ▸ | ACHE | P22303 | 2/20 | 0.62 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.62 |
| ▸ | ESR1 | P03372 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 1/20 | 0.62 |
| ▸ | BLM | P54132 | 1/20 | 0.62 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.58 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.55 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.55 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.55 |
| ▸ | ADORA2B | P29275 | 6/20 | 0.55 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | TNF | P01375 | 2/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10346307 | 0.95 | LMNA (0.61) | PDE4ALMNACYP1A2NFKB1ACHE | |
| SCHEMBL10346583 | 0.94 | PDE4A (0.64) | PDE4ALMNACYP1A2NFKB1ACHE | |
| SCHEMBL5427270 | 0.94 | PDE4A (0.70) | PDE4ALMNACYP1A2NFKB1ACHE | |
| SCHEMBL7358934 | 0.93 | PDE4A (0.69) | PDE4ALMNACYP1A2NFKB1ACHE | |
| SCHEMBL10346588 | 0.91 | PDE4A (0.68) | PDE4ALMNACYP1A2NFKB1ACHE | |
| SCHEMBL19601304 | 0.91 | PDE4A (0.58) | PDE4ALMNACYP1A2NFKB1ACHE | |
| SCHEMBL9057453 | 0.90 | PDE4A (0.60) | PDE4ALMNACYP1A2NFKB1ACHE | |
| SCHEMBL7033527 | 0.89 | PDE4A (0.58) | PDE4ALMNACYP1A2NFKB1ACHE | |
| SCHEMBL10346304 | 0.88 | LMNA (0.56) | PDE4ALMNACYP1A2NFKB1ACHE | |
| SCHEMBL11059115 | 0.88 | PDE4A (0.73) | PDE4ALMNACYP1A2NFKB1ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6432968-B1 | IMMUNOSUPPRESSANTS FOR PATIENTS WITH CANCER, AUTOIMMUNE DISEASES, AND VIRAL INFECTIONS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2002-08-13 | — | — | US | claimed |
| EP-0797448-A2 | COMBINATION PREPARATION, CONTAINING CYCLOSPORIN A OR FK506 OR RAPAMYCIN AND A XANTHINE DERIVATIVE | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-10-01 | — | — | EP | claimed |
| WO-1996005854-A2 | COMBINATION PREPARATION, CONTAINING CYCLOSPORIN A OR FK506 OR RAPAMYCIN AND A XANTHINE DERIVATIVE | HOECHST AKTIENGESELLSCHAFT (DE) | 1996-02-29 | — | — | WO | claimed |
| EP-0797448-B1 | COMBINATION PREPARATION, CONTAINING CYCLOSPORIN A OR FK506 OR RAPAMYCIN AND A XANTHINE DERIVATIVE | HOECHST AG (DE) | 2003-02-26 | — | — | EP | disclosed |
| US-6432968-B1 | IMMUNOSUPPRESSANTS FOR PATIENTS WITH CANCER, AUTOIMMUNE DISEASES, AND VIRAL INFECTIONS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2002-08-13 | — | — | US | disclosed |
| US-6046328-A | Combination preparation, containing cyclosporin A or FK506 or rapamycin and a xanthine derivative | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2000-04-04 | — | — | US | disclosed |
| EP-0797448-A2 | COMBINATION PREPARATION, CONTAINING CYCLOSPORIN A OR FK506 OR RAPAMYCIN AND A XANTHINE DERIVATIVE | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-10-01 | — | — | EP | disclosed |
| WO-1996005854-A2 | COMBINATION PREPARATION, CONTAINING CYCLOSPORIN A OR FK506 OR RAPAMYCIN AND A XANTHINE DERIVATIVE | HOECHST AKTIENGESELLSCHAFT (DE) | 1996-02-29 | — | — | WO | disclosed |