Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 11/20 | 0.71 |
| ▸ | ACE | P12821 | 11/20 | 0.67 |
| ▸ | CPA1 | P15085 | 8/20 | 0.67 |
| ▸ | ACE2 | Q9BYF1 | 8/20 | 0.67 |
| ▸ | MMP2 | P08253 | 1/20 | 0.55 |
| ▸ | MMP7 | P09237 | 1/20 | 0.55 |
| ▸ | MMP9 | P14780 | 1/20 | 0.55 |
| ▸ | MMP12 | P39900 | 1/20 | 0.55 |
| ▸ | MMP13 | P45452 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7032093 | 1.00 | MME (0.71) | MMEACECPA1ACE2MMP2 | |
| SCHEMBL6418586 | 0.91 | MME (0.61) | MMEACECPA1ACE2MMP2 | |
| SCHEMBL7382794 | 0.91 | ACE (0.74) | MMEACECPA1ACE2 | |
| SCHEMBL8005905 | 0.90 | MME (0.87) | MMEACECPA1ACE2MMP2 | |
| SCHEMBL7365144 | 0.89 | ACE (0.73) | MMEACECPA1ACE2MMP2 | |
| SCHEMBL27484783 | 0.88 | MME (0.74) | MMEACECPA1ACE2MMP2 | |
| SCHEMBL27484784 | 0.88 | MME (0.74) | MMEACECPA1ACE2MMP2 | |
| SCHEMBL8387156 | 0.88 | MME (0.74) | MMEACECPA1ACE2MMP2 | |
| SCHEMBL7028034 | 0.87 | MME (0.72) | MMEACECPA1ACE2 | |
| SCHEMBL8387195 | 0.86 | MME (0.65) | MMEACECPA1ACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0728144-B1 | PEPTIDYL COMPOUNDS AND THEIR THERAPEUTIC USE AS INHIBITORS OF METALLOPROTEINASES | DARWIN DISCOVERY LTD (GB) | 2000-01-19 | — | — | EP | claimed |
| EP-1140984-B1 | SELECTIVE INHIBITORS OF MMP-12 | AVENTIS PHARMA INC (US) | 2003-02-12 | — | — | EP | disclosed |
| US-6352976-B1 | ENZYME INHIBITORS OF MATRIX METALLOPROTEINASE FOR EMPHYSEMA | AVENTIS PHARMACEUTICALS INC. | 2002-03-05 | — | — | US | disclosed |
| EP-1140984-A1 | SELECTIVE INHIBITORS OF MMP-12 | Aventis Pharmaceuticals Inc. (US) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000040600-A1 | SELECTIVE INHIBITORS OF MMP-12 | AVENTIS PHARMACEUTICALS INC. (US) | 2000-07-13 | — | — | WO | disclosed |