Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 13/20 | 0.72 |
| ▸ | ACE | P12821 | 13/20 | 0.72 |
| ▸ | CPA1 | P15085 | 10/20 | 0.72 |
| ▸ | ACE2 | Q9BYF1 | 10/20 | 0.72 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.52 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7032149 | 0.87 | MME (0.61) | MMEACECPA1ACE2 | |
| SCHEMBL7032146 | 0.87 | MME (0.61) | MMEACECPA1ACE2 | |
| SCHEMBL7032097 | 0.87 | MME (0.71) | MMEACECPA1ACE2 | |
| SCHEMBL7032093 | 0.87 | MME (0.71) | MMEACECPA1ACE2 | |
| SCHEMBL7029129 | 0.86 | MME (0.64) | MMEACECPA1ACE2 | |
| SCHEMBL7029115 | 0.86 | MME (0.64) | MMEACECPA1ACE2 | |
| SCHEMBL7382794 | 0.84 | ACE (0.74) | MMEACECPA1ACE2 | |
| SCHEMBL7031374 | 0.84 | ACE (0.73) | MMEACECPA1ACE2 | |
| SCHEMBL7031031 | 0.83 | MME (0.63) | MMEACECPA1ACE2HDAC3 | |
| SCHEMBL23643094 | 0.80 | ACE (0.60) | MMEACECPA1ACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140984-B1 | SELECTIVE INHIBITORS OF MMP-12 | AVENTIS PHARMA INC (US) | 2003-02-12 | — | — | EP | disclosed |
| US-6352976-B1 | ENZYME INHIBITORS OF MATRIX METALLOPROTEINASE FOR EMPHYSEMA | AVENTIS PHARMACEUTICALS INC. | 2002-03-05 | — | — | US | disclosed |
| EP-1140984-A1 | SELECTIVE INHIBITORS OF MMP-12 | Aventis Pharmaceuticals Inc. (US) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000040600-A1 | SELECTIVE INHIBITORS OF MMP-12 | AVENTIS PHARMACEUTICALS INC. (US) | 2000-07-13 | — | — | WO | disclosed |