Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 9/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | GAA | P10253 | 3/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | MLLT1 | Q03111 | 1/20 | 0.33 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6418049 | 1.00 | HPGDS (0.40) | HPGDSEPHX2KDM1ANPC1RAB9A | |
| SCHEMBL6413447 | 0.90 | HPGDS (0.40) | HPGDSNPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL7029824 | 0.90 | HPGDS (0.40) | HPGDSNPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL6411631 | 0.86 | KDM1A (0.37) | EPHX2KDM1ANPC1RAB9AUSP30 | |
| SCHEMBL6416483 | 0.84 | HPGDS (0.44) | HPGDSNPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL6418639 | 0.84 | HPGDS (0.42) | HPGDSNPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL6413940 | 0.84 | HPGDS (0.42) | HPGDSNPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL6414532 | 0.82 | HPGDS (0.38) | HPGDSEPHX2NPC1RAB9AUSP30 | |
| SCHEMBL6413769 | 0.82 | EPHX2 (0.35) | HPGDSEPHX2NPC1RAB9AUSP30 | |
| SCHEMBL6411893 | 0.80 | NAMPT (0.46) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1476449-A1 | FUSED BICYCLIC-N-BRIDGED-HETEROAROMATIC CARBOXAMIDES FOR THE TREATMENT OF DISEASE | PHARMACIA & UPJOHN COMPANY (US) | 2004-11-17 | — | — | EP | disclosed |
| WO-2003070732-A1 | FUSED BICYCLIC-N-BRIDGED-HETEROAROMATIC CARBOXAMIDES FOR THE TREATMENT OF DISEASE | PHARMACIA & UPJOHN COMPANY (US) | 2003-08-28 | — | — | WO | disclosed |