Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 10/20 | 0.35 |
| ▸ | HTR2A | P28223 | 3/20 | 0.34 |
| ▸ | HTR2C | P28335 | 3/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | HBB | P68871 | 1/20 | 0.32 |
| ▸ | PARP1 | P09874 | 1/20 | 0.31 |
| ▸ | RORC | P51449 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7036976 | 0.85 | HTR2C (0.38) | HTR6HTR2AHTR2CALOX15KDM4E | |
| SCHEMBL7037086 | 0.81 | HTR2C (0.34) | HTR6HTR2AHTR2CALOX15KDM4E | |
| SCHEMBL7038313 | 0.77 | HTR2C (0.38) | HTR6HTR2AHTR2CALOX15KDM4E | |
| SCHEMBL7033469 | 0.75 | HTR6 (0.33) | HTR6HTR2AHTR2CALOX15KDM4E | |
| Oxalic Acid SCHEMBL6496999 | 0.75 | HTR6 (0.38) | HTR6HTR2AHTR2CALOX15KDM4E | |
| SCHEMBL6507609 | 0.73 | HTR6 (0.41) | HTR6HTR2AHTR2CALOX15KDM4E | |
| SCHEMBL7036278 | 0.69 | HTR6 (0.35) | HTR6HTR2AHTR2CALOX15KDM4E | |
| Oxalic Acid SCHEMBL6496099 | 0.69 | HTR2C (0.42) | HTR6HTR2AHTR2CALOX15KDM4E | |
| SCHEMBL7031084 | 0.68 | HTR6 (0.35) | HTR6HTR2AHTR2CALOX15KDM4E | |
| SCHEMBL7033912 | 0.67 | HTR6 (0.33) | HTR6HTR2AHTR2CALOX15KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1173440-B1 | TETRACYCLIC AZEPINOINDOLE COMPOUNDS AS 5-HT RECEPTOR LIGANDS | UPJOHN CO (US) | 2004-09-15 | — | — | EP | claimed |