⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2540688 | 0.73 | — | — | |
| SCHEMBL264926 | 0.73 | — | — | |
| SCHEMBL199619 | 0.71 | — | — | |
| SCHEMBL27348061 | 0.69 | HDAC2 (0.48) | — | |
| SCHEMBL8600653 | 0.69 | HDAC2 (0.48) | — | |
| SCHEMBL27795833 | 0.69 | HDAC2 (0.48) | — | |
| SCHEMBL7823464 | 0.69 | — | — | |
| SCHEMBL11581061 | 0.69 | — | — | |
| SCHEMBL10526877 | 0.69 | — | — | |
| SCHEMBL3438969 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2768554-B2 | — | — | 1998-06-25 | — | — | JP | claimed |
| EP-0651739-B1 | HYDROXAMIC ACID DERIVATIVES AS METALLOPROTEINASE INHIBITORS | BRITISH BIOTECH PHARM (GB) | 1997-04-09 | — | — | EP | claimed |
| EP-0651739-A1 | HYDROXAMIC ACID DERIVATIVES AS METALLOPROTEINASE INHIBITORS. | BRITISH BIOTECH PHARM (GB) | 1995-05-10 | — | — | EP | claimed |
| WO-1994002447-A1 | HYDROXAMIC ACID DERIVATIVES AS METALLOPROTEINASE INHIBITORS | BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) | 1994-02-03 | — | — | WO | claimed |
| EP-0977730-B1 | AMINO ACID DERIVATIVES INHIBITING EXTRACELLULAR MATRIX METALLOPROTEINASE AND TNF ALPHA RELEASE | CHIESI FARMA SPA (IT) | 2003-03-12 | — | — | EP | disclosed |
| EP-0977730-A1 | AMINO ACID DERIVATIVES INHIBITING EXTRACELLULAR MATRIX METALLOPROTEINASE AND TNF ALPHA RELEASE | CHIESI FARMACEUTICI S.p.A. (IT) | 2000-02-09 | — | — | EP | disclosed |
| WO-1998047863-A1 | AMINO ACID DERIVATIVES INHIBITING EXTRACELLULAR MATRIX METALLOPROTEINASE AND TNF ALPHA RELEASE | CHIESI FARMACEUTICI S.P.A. (IT) | 1998-10-29 | — | — | WO | disclosed |
| EP-0861226-A1 | SYNTHESIS OF CARBOXYLIC ACID DERIVATIVES | BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) | 1998-09-02 | — | — | EP | disclosed |
| US-5700838-A | Hydroxamic acid derivatives as metalloproteinase inhibitors | BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) | 1997-12-23 | — | — | US | disclosed |
| WO-1997019050-A1 | SYNTHESIS OF CARBOXYLIC ACID DERIVATIVES | BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) | 1997-05-29 | — | — | WO | disclosed |
| EP-0651739-B1 | HYDROXAMIC ACID DERIVATIVES AS METALLOPROTEINASE INHIBITORS | BRITISH BIOTECH PHARM (GB) | 1997-04-09 | — | — | EP | disclosed |
| EP-0754688-A2 | Dioxolane intermediates | BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) | 1997-01-22 | — | — | EP | disclosed |
| EP-0651739-A1 | HYDROXAMIC ACID DERIVATIVES AS METALLOPROTEINASE INHIBITORS. | BRITISH BIOTECH PHARM (GB) | 1995-05-10 | — | — | EP | disclosed |
| WO-1994002447-A1 | HYDROXAMIC ACID DERIVATIVES AS METALLOPROTEINASE INHIBITORS | BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) | 1994-02-03 | — | — | WO | disclosed |
| US-4857521-A | Trialkylsilyl pyridinium cephalosporin antibiotics | SANWA KAGAKU KENKYUSHO CO., LTD. (JP) | 1989-08-15 | — | — | US | disclosed |
| US-4717767-A | ANTIBIOTICS | TOYAMA CHEMICAL CO., LTD. (JP) | 1988-01-05 | — | — | US | disclosed |
| EP-0231124-A2 | Cephalosporin derivatives, salts thereof, process for their manufacture, and pharmaceutical agents comprising them | SANWA KAGAKU KENKYUSHO CO., LTD. (JP) | 1987-08-05 | — | — | EP | disclosed |
| US-4618606-A | Antibiotic 7-(thiazolyl)-3-(pyrazinylmethyl) or (pyridazinylmethyl) cephalosporins | TOYAMA CHEMICAL CO., LTD. (JP) | 1986-10-21 | — | — | US | disclosed |
| US-4546176-A | 7-Carboxymethoxyphenylacetamido-3-cephem derivatives and antibacterial preparations containing the same | EISAI CO., LTD. (JP) | 1985-10-08 | — | — | US | disclosed |