Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lithium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 14/20 | 0.81 |
| ▸ | PPARA | Q07869 | 7/20 | 0.81 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.57 |
| ▸ | FLT1 | P17948 | 1/20 | 0.56 |
| ▸ | FLT4 | P35916 | 1/20 | 0.56 |
| ▸ | KDR | P35968 | 1/20 | 0.56 |
| ▸ | SERPINE1 | P05121 | 2/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lithium Ion SCHEMBL7038912 | 0.98 | PPARG (0.82) | PPARGPPARAKDM4ENPSR1RXFP1 | |
| Lithium Ion SCHEMBL7034509 | 0.91 | PPARG (0.69) | PPARGPPARASERPINE1TP53 | |
| SCHEMBL7038130 | 0.89 | SERPINE1 (0.70) | PPARGPPARAKDM4ENPSR1RXFP1 | |
| SCHEMBL7040843 | 0.86 | PPARG (0.69) | PPARGPPARAKDM4ENPSR1RXFP1 | |
| Lithium Ion SCHEMBL7040859 | 0.86 | PPARG (0.70) | PPARGPPARATP53HDAC8HDAC6 | |
| Lithium Ion SCHEMBL7036019 | 0.86 | PPARG (0.71) | PPARGPPARAKDM4ERXFP1TP53 | |
| Lithium Ion SCHEMBL7037651 | 0.84 | PPARG (0.75) | PPARGPPARASERPINE1TP53 | |
| SCHEMBL7040693 | 0.84 | PPARG (0.60) | PPARGPPARAKDM4ENPSR1RXFP1 | |
| Lithium Ion SCHEMBL7038667 | 0.84 | PPARG (1.00) | PPARGPPARA | |
| Lithium Ion SCHEMBL7146523 | 0.84 | ACLY (0.68) | PPARGPPARAKDM4ENPSR1RXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030073862-A1 | Compounds | BIOVITRUM AB (SE) | 2003-04-17 | — | — | US | disclosed |
| WO-2003004458-A1 | NEW COMPOUNDS | BIOVITRUM AB (SE) | 2003-01-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030073862-A1 | Compounds | PPARG, PPARA, PPARD | PPARG 1/4885PPARA 2/4885KDM4E 2125/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.