Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1H | O95180 | 12/20 | 0.72 |
| ▸ | CACNA1C | Q13936 | 10/20 | 0.72 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.66 |
| ▸ | MAPT | P10636 | 4/20 | 0.66 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.66 |
| ▸ | CACNA1B | Q00975 | 3/20 | 0.66 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.66 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.66 |
| ▸ | NPC1 | O15118 | 1/20 | 0.66 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.66 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.66 |
| ▸ | TP53 | P04637 | 1/20 | 0.66 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.66 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.66 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.66 |
| ▸ | HTR1A | P08908 | 1/20 | 0.66 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.66 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.66 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.66 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3701163 | 0.96 | CACNA1H (0.68) | CACNA1HCACNA1CCYP3A4MAPTCYP2D6 | |
| SCHEMBL3701161 | 0.96 | CACNA1H (0.68) | CACNA1HCACNA1CCYP3A4MAPTCYP2D6 | |
| SCHEMBL7037268 | 0.90 | CACNA1H (0.65) | CACNA1HCACNA1CCYP3A4MAPTCYP2D6 | |
| Mibefradil SCHEMBL12250872 | 0.90 | CACNA1H (0.67) | CACNA1HCACNA1CCYP3A4MAPTCYP2D6 | |
| SCHEMBL3701989 | 0.89 | CACNA1H (0.89) | CACNA1HCACNA1CCYP3A4MAPTCYP2D6 | |
| SCHEMBL3701997 | 0.89 | CACNA1H (0.89) | CACNA1HCACNA1CCYP3A4MAPTCYP2D6 | |
| SCHEMBL3701992 | 0.89 | CACNA1H (0.89) | CACNA1HCACNA1CCYP3A4MAPTCYP2D6 | |
| SCHEMBL3695557 | 0.86 | CACNA1H (0.62) | CACNA1HCACNA1CCYP3A4MAPTCYP2D6 | |
| SCHEMBL3695558 | 0.86 | CACNA1H (0.62) | CACNA1HCACNA1CCYP3A4MAPTCYP2D6 | |
| Mibefradil SCHEMBL2413997 | 0.86 | CACNA1H (0.64) | CACNA1HCACNA1CCYP3A4MAPTCYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8575361-B2 | Tetrahydronaphthalene derivatives | CONCERT PHARMACEUTICALS INC. (US) | 2013-11-05 | — | — | US | disclosed |
| US-20120122944-A1 | TETRAHYDRONAPHTHALENE DERIVATIVES | CONCERT PHARMACEUTICALS INC. (US) | 2012-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120122944-A1 | TETRAHYDRONAPHTHALENE DERIVATIVES | CACNA1H, CACNA1I, CACNA1G | CACNA1H 1/4885CACNA1C 8/4885CYP3A4 1582/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.