Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 2/20 | 0.47 |
| ▸ | ACHE | P22303 | 2/20 | 0.47 |
| ▸ | TACR1 | P25103 | 1/20 | 0.41 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.40 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.39 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.38 |
| ▸ | MTOR | P42345 | 1/20 | 0.38 |
| ▸ | NR1D1 | P20393 | 1/20 | 0.38 |
| ▸ | SSTR4 | P31391 | 2/20 | 0.37 |
| ▸ | SSTR5 | P35346 | 2/20 | 0.37 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | CTSV | O60911 | 1/20 | 0.37 |
| ▸ | CTSL | P07711 | 1/20 | 0.37 |
| ▸ | CTSB | P07858 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31103697 | 0.98 | BCHE (0.47) | BCHEACHETACR1AGTR2ABCB1 | |
| SCHEMBL31103847 | 0.88 | ALDH1A1 (0.44) | BCHEACHETACR1ABCB1PDPK1 | |
| SCHEMBL31103615 | 0.88 | TACR1 (0.42) | BCHEACHETACR1AGTR2ABCB1 | |
| SCHEMBL14199452 | 0.85 | KLK7 (0.47) | BCHEACHETACR1AGTR2ABCB1 | |
| SCHEMBL11445442 | 0.85 | BCHE (0.47) | BCHEACHEAGTR2SSTR4SSTR5 | |
| SCHEMBL7031703 | 0.85 | BCHE (0.44) | BCHEACHETACR1AGTR2PDPK1 | |
| SCHEMBL31103786 | 0.83 | BCHE (0.41) | BCHEACHETACR1AGTR2ABCB1 | |
| SCHEMBL7032891 | 0.81 | BCHE (0.52) | BCHEACHETACR1PDPK1MTOR | |
| SCHEMBL31420955 | 0.80 | ALDH1A1 (0.47) | HCRTR2ALDH1A1 | |
| SCHEMBL25218303 | 0.78 | NR1H2 (0.41) | BCHEACHETACR1AGTR2SSTR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0858335-B1 | 2-ALKYLPYRROLIDINES | NOVO NORDISK AS (DK) | 2003-03-12 | — | — | EP | disclosed |
| US-6451836-B1 | Method of inhibiting liver glycogen phosphorylase with 2-alkylpyrrolidines | NOVO NORDISK A/S (DK) | 2002-09-17 | — | — | US | disclosed |
| EP-1040827-A2 | Use of 2-alkylpyrrolidines for the treatment of diabetes | NOVO NORDISK A/S (DK) | 2000-10-04 | — | — | EP | disclosed |
| US-5854272-A | 2-alkylpyrrolidines | NOVO NORDISK A/S (DK) | 1998-12-29 | — | — | US | disclosed |
| EP-0884050-A1 | Use of 3,4-dihydroxy-2-hydroxymethylpyrrolidine for the treatment of diabetes | NOVO NORDISK A/S (DK) | 1998-12-16 | — | — | EP | disclosed |
| EP-0858335-A1 | 2-ALKYLPYRROLIDINES | NOVO NORDISK A/S (DK) | 1998-08-19 | — | — | EP | disclosed |
| WO-1997009040-A1 | 2-ALKYLPYRROLIDINES | NOVO NORDISK A/S (DK) | 1997-03-13 | — | — | WO | disclosed |