Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Lysine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIK1 | P39086 | 1/20 | 0.69 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.69 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.69 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.69 |
| ▸ | GSR | P00390 | 1/20 | 0.69 |
| ▸ | ARG2 | P78540 | 4/20 | 0.44 |
| ▸ | ARG1 | P05089 | 3/20 | 0.44 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.43 |
| ▸ | TET2 | Q6N021 | 3/20 | 0.41 |
| ▸ | TET3 | O43151 | 1/20 | 0.41 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.41 |
| ▸ | NOS3 | P29474 | 2/20 | 0.40 |
| ▸ | NOS1 | P29475 | 2/20 | 0.40 |
| ▸ | NOS2 | P35228 | 2/20 | 0.40 |
| ▸ | GGT1 | P19440 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lysine SCHEMBL27844641 | 0.83 | GSR (0.91) | GRIK1GRIK2GRM1GRM2GSR | |
| Lysine SCHEMBL16194519 | 0.83 | GSR (0.91) | GRIK1GRIK2GRM1GRM2GSR | |
| Lysine SCHEMBL28262210 | 0.83 | GSR (0.91) | GRIK1GRIK2GRM1GRM2GSR | |
| Lysine SCHEMBL28744335 | 0.83 | GSR (0.91) | GRIK1GRIK2GRM1GRM2GSR | |
| Lysine SCHEMBL8508321 | 0.83 | GSR (0.91) | GRIK1GRIK2GRM1GRM2GSR | |
| Lysine SCHEMBL16194517 | 0.83 | GSR (0.91) | GRIK1GRIK2GRM1GRM2GSR | |
| Lysine SCHEMBL8508320 | 0.83 | GSR (0.91) | GRIK1GRIK2GRM1GRM2GSR | |
| Lysine SCHEMBL9439278 | 0.83 | GSR (1.00) | GRIK1GRIK2GRM1GRM2GSR | |
| Lysine SCHEMBL7343 | 0.83 | GSR (1.00) | GRIK1GRIK2GRM1GRM2GSR | |
| Lysine SCHEMBL1645 | 0.83 | GSR (1.00) | GRIK1GRIK2GRM1GRM2GSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0731648-B1 | FLAVOURING COMPOSITIONS AND METHOD | FIRMENICH & CIE (CH) | 2003-03-26 | — | — | EP | claimed |