Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 8/20 | 0.49 |
| ▸ | MAPK13 | O15264 | 7/20 | 0.49 |
| ▸ | MAPK12 | P53778 | 7/20 | 0.49 |
| ▸ | MAPK11 | Q15759 | 7/20 | 0.49 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | TYK2 | P29597 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7032178 | 0.93 | MAPK14 (0.49) | MAPK14MAPK13MAPK12MAPK11GRM4 | |
| SCHEMBL7033588 | 0.91 | MAPK14 (0.57) | MAPK14MAPK13MAPK12MAPK11GRM4 | |
| SCHEMBL7036631 | 0.84 | RAB9A (0.46) | MAPK14MAPK13MAPK12MAPK11GRM4 | |
| SCHEMBL7033514 | 0.82 | MAPK14 (0.51) | MAPK14MAPK13MAPK12MAPK11GRM4 | |
| SCHEMBL1901734 | 0.81 | MAPK14 (0.71) | MAPK14MAPK13MAPK12MAPK11NPSR1 | |
| SCHEMBL1899616 | 0.80 | MAPK14 (0.61) | MAPK14MAPK13MAPK12MAPK11NPSR1 | |
| SCHEMBL7039968 | 0.80 | MAPK14 (0.69) | MAPK14MAPK13MAPK12MAPK11GRM4 | |
| SCHEMBL7040292 | 0.79 | MAPK14 (0.54) | MAPK14MAPK13MAPK12MAPK11MEN1 | |
| SCHEMBL7040238 | 0.78 | MAPK14 (0.53) | MAPK14MAPK13MAPK12MAPK11GRM4 | |
| SCHEMBL7038383 | 0.78 | MAPK14 (0.47) | MAPK14MAPK13MAPK12MAPK11GRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1289958-A2 | BENZOPHENONES AS INHIBITORS OF IL-1$g(b) AND TNF-$g(a) | Leo Pharma A/S (DK) | 2003-03-12 | — | — | EP | claimed |
| WO-2001090074-A2 | BENZOPHENONES AS INHIBITORS OF IL-1β AND TNF-$g(a) | LEO PHARMA A/S (DK) | 2001-11-29 | — | — | WO | claimed |