Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB3 | P13945 | 13/20 | 0.57 |
| ▸ | YAP1 | P46937 | 1/20 | 0.42 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | GPR88 | Q9GZN0 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7038441 | 0.88 | ADRB3 (0.52) | ADRB3 | |
| SCHEMBL7038435 | 0.88 | ADRB3 (0.52) | ADRB3 | |
| SCHEMBL7044291 | 0.87 | ADRB3 (0.60) | ADRB3 | |
| SCHEMBL7036260 | 0.81 | ADRB3 (0.42) | ADRB3 | |
| SCHEMBL8817454 | 0.78 | ADRB3 (0.47) | ADRB3 | |
| SCHEMBL7044277 | 0.78 | ADRB3 (0.52) | ADRB3 | |
| SCHEMBL7044253 | 0.78 | ADRB3 (0.52) | ADRB3 | |
| SCHEMBL7044256 | 0.78 | ADRB3 (0.52) | ADRB3 | |
| SCHEMBL7040250 | 0.78 | ADRB3 (0.52) | ADRB3 | |
| SCHEMBL7040219 | 0.77 | ADRB3 (0.61) | ADRB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0659737-B1 | Catecholamine surrogates useful as beta 3 agonists | BRISTOL MYERS SQUIBB CO (US) | 2003-03-26 | — | — | EP | disclosed |
| EP-0659737-A2 | Catecholamine surrogates useful as B3 agonists | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-06-28 | — | — | EP | disclosed |