Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB3 | P13945 | 18/20 | 0.52 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.41 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7038435 | 1.00 | ADRB3 (0.52) | ADRB3ADRB2ADRB1HDAC3HDAC1 | |
| SCHEMBL7044291 | 0.92 | ADRB3 (0.60) | ADRB3 | |
| SCHEMBL7036712 | 0.88 | ADRB3 (0.57) | ADRB3 | |
| SCHEMBL7036260 | 0.88 | ADRB3 (0.42) | ADRB3ADRB2ADRB1 | |
| SCHEMBL8817454 | 0.84 | ADRB3 (0.47) | ADRB3ADRB2ADRB1HDAC3HDAC1 | |
| SCHEMBL7044256 | 0.84 | ADRB3 (0.52) | ADRB3ADRB2ADRB1 | |
| SCHEMBL7044277 | 0.84 | ADRB3 (0.52) | ADRB3ADRB2ADRB1 | |
| SCHEMBL7040250 | 0.84 | ADRB3 (0.52) | ADRB3ADRB2ADRB1 | |
| SCHEMBL7044253 | 0.84 | ADRB3 (0.52) | ADRB3ADRB2ADRB1 | |
| SCHEMBL7040219 | 0.83 | ADRB3 (0.61) | ADRB3ADRB2ADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0659737-B1 | Catecholamine surrogates useful as beta 3 agonists | BRISTOL MYERS SQUIBB CO (US) | 2003-03-26 | — | — | EP | disclosed |
| EP-0659737-A2 | Catecholamine surrogates useful as B3 agonists | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-06-28 | — | — | EP | disclosed |