Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 5/20 | 0.52 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | SYK | P43405 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | CD63 | P08962 | 1/20 | 0.46 |
| ▸ | TMIGD3 | P0DMS9 | 2/20 | 0.46 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.45 |
| ▸ | CLK1 | P49759 | 1/20 | 0.45 |
| ▸ | CLK2 | P49760 | 1/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.45 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.45 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.45 |
| ▸ | GHSR | Q92847 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7041330 | 0.88 | AURKA (0.59) | AURKAADORA1SYKPOLBCD63 | |
| SCHEMBL6222008 | 0.80 | EPHB4 (0.53) | AURKASYKCD63TMIGD3EPHB4 | |
| SCHEMBL5478336 | 0.73 | RAB9A (0.59) | AURKAADORA1NPC1RAB9ASYK | |
| SCHEMBL5478121 | 0.71 | EPHB4 (0.64) | AURKAEPHB4 | |
| SCHEMBL21167350 | 0.71 | TRIM33 (0.42) | AURKANPC1RAB9AKDM4ECLK1 | |
| SCHEMBL5408059 | 0.70 | ADORA1 (0.68) | AURKAADORA1NPC1RAB9AKDM4E | |
| SCHEMBL1844199 | 0.69 | MAPT (0.82) | NPC1RAB9AGAAKDM4EALDH1A1 | |
| SCHEMBL5669873 | 0.69 | MAPT (0.82) | NPC1RAB9AGAAKDM4EALDH1A1 | |
| SCHEMBL10055019 | 0.69 | MAPT (0.82) | NPC1RAB9AGAAKDM4EALDH1A1 | |
| SCHEMBL5483666 | 0.68 | EPHB4 (0.56) | AURKAADORA1NPC1RAB9AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030212073-A1 | Imidazo[1,2-a]pyrazin-8-ylamines, method of making, and method of use thereof | GILEAD CONNECTICUT, INC. | 2003-11-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030212073-A1 | Imidazo[1,2-a]pyrazin-8-ylamines, method of making, and method of use thereof | PRKACA, MAP3K8, MAP3K1 | AURKA 227/4885ADORA1 1345/4885NPC1 1362/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.