Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | APAF1 | O14727 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | THRB | P10828 | 1/20 | 0.53 |
| ▸ | XBP1 | P17861 | 1/20 | 0.53 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | GALK1 | P51570 | 1/20 | 0.53 |
| ▸ | BLM | P54132 | 1/20 | 0.53 |
| ▸ | SMAD3 | P84022 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | MAOA | P21397 | 3/20 | 0.51 |
| ▸ | MAOB | P27338 | 3/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25567548 | 0.85 | MEN1 (0.53) | MEN1APAF1NPC1LMNAMAPT | |
| SCHEMBL17490088 | 0.81 | MEN1 (0.47) | MEN1APAF1NPC1LMNAMAPT | |
| SCHEMBL7040574 | 0.81 | GSTP1 (0.50) | MEN1NPC1LMNAMAPTRAB9A | |
| SCHEMBL17485071 | 0.76 | MEN1 (0.47) | MEN1APAF1NPC1LMNAMAPT | |
| SCHEMBL17489710 | 0.76 | MEN1 (0.47) | MEN1APAF1NPC1LMNAMAPT | |
| SCHEMBL327855 | 0.74 | MEN1 (0.59) | MEN1APAF1NPC1LMNAMAPT | |
| SCHEMBL30821965 | 0.74 | MEN1 (0.59) | MEN1APAF1NPC1LMNAMAPT | |
| SCHEMBL14252283 | 0.74 | MEN1 (0.59) | MEN1APAF1NPC1LMNAMAPT | |
| SCHEMBL17489674 | 0.73 | ATM (0.46) | MEN1APAF1NPC1LMNAMAPT | |
| SCHEMBL13507781 | 0.73 | KDM4E (0.41) | MEN1APAF1NPC1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0944636-B1 | PHENYL GLYOXAMIDES AS sPLA2 INHIBITORS | LILLY CO ELI (US) | 2003-03-19 | — | — | EP | disclosed |
| EP-0944636-A4 | PHENYL GLYOXAMIDES AS sPLA2 INHIBITORS | LILLY CO ELI (US) | 2000-07-12 | — | — | EP | disclosed |
| EP-0944636-A1 | PHENYL GLYOXAMIDES AS sPLA2 INHIBITORS | ELI LILLY AND COMPANY (US) | 1999-09-29 | — | — | EP | disclosed |
| US-5916922-A | FOR INHIBITING HUMAN NON-PANCREATIC SECRETORY PHOSPHOLIPASE A2 | ELI LILLY AND COMPANY (US) | 1999-06-29 | — | — | US | disclosed |
| WO-1998024794-A1 | PHENYL GLYOXAMIDES AS sPLA2 INHIBITORS | ELI LILLY AND COMPANY (US) | 1998-06-11 | — | — | WO | disclosed |