Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSTP1 | P09211 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | MAOA | P21397 | 3/20 | 0.46 |
| ▸ | MAOB | P27338 | 3/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.43 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | PLIN5 | Q00G26 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7039366 | 0.81 | MEN1 (0.53) | MAPTL3MBTL1MAOAMAOBRAB9A | |
| SCHEMBL16361075 | 0.75 | LTA4H (0.55) | GSTP1MAPTMAOAMAOBFFAR1 | |
| SCHEMBL12774688 | 0.74 | MAOA (0.49) | GSTP1MAPTTDP1L3MBTL1MAOA | |
| SCHEMBL19891793 | 0.73 | FFAR4 (0.61) | GSTP1MAPTMAOAMAOBFFAR1 | |
| SCHEMBL10453614 | 0.73 | FFAR4 (0.61) | GSTP1MAPTMAOAMAOBFFAR1 | |
| SCHEMBL4536542 | 0.73 | LTA4H (0.60) | GSTP1MAPTMAOAMAOBFFAR1 | |
| SCHEMBL11820920 | 0.73 | LTA4H (0.60) | GSTP1MAPTMAOAMAOBFFAR1 | |
| SCHEMBL11409557 | 0.73 | LTA4H (0.52) | GSTP1MAPTTDP1MAOAMAOB | |
| SCHEMBL11818162 | 0.71 | FFAR1 (0.55) | GSTP1MAPTMAOAMAOBFFAR1 | |
| SCHEMBL11814889 | 0.71 | FFAR4 (0.59) | GSTP1MAPTMAOAMAOBFFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0944636-B1 | PHENYL GLYOXAMIDES AS sPLA2 INHIBITORS | LILLY CO ELI (US) | 2003-03-19 | — | — | EP | disclosed |
| EP-0944636-A4 | PHENYL GLYOXAMIDES AS sPLA2 INHIBITORS | LILLY CO ELI (US) | 2000-07-12 | — | — | EP | disclosed |
| EP-0944636-A1 | PHENYL GLYOXAMIDES AS sPLA2 INHIBITORS | ELI LILLY AND COMPANY (US) | 1999-09-29 | — | — | EP | disclosed |
| US-5916922-A | FOR INHIBITING HUMAN NON-PANCREATIC SECRETORY PHOSPHOLIPASE A2 | ELI LILLY AND COMPANY (US) | 1999-06-29 | — | — | US | disclosed |
| WO-1998024794-A1 | PHENYL GLYOXAMIDES AS sPLA2 INHIBITORS | ELI LILLY AND COMPANY (US) | 1998-06-11 | — | — | WO | disclosed |