Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 4/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.31 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.31 |
| ▸ | PPARD | Q03181 | 1/20 | 0.31 |
| ▸ | PPARA | Q07869 | 1/20 | 0.31 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7040676 | 0.85 | GRM2 (0.37) | GRM2PPARGNR1H2PPARDPPARA | |
| SCHEMBL6559345 | 0.79 | GRM2 (0.40) | GRM2PPARGNR1H2PPARDPPARA | |
| SCHEMBL8668094 | 0.78 | GRM2 (0.36) | GRM2PPARGNR1H2PPARDPPARA | |
| SCHEMBL7040442 | 0.69 | PPARA (0.52) | GRM2PPARGPPARDPPARA | |
| SCHEMBL7039487 | 0.67 | PPARD (0.42) | PPARGNR1H2PPARDPPARANR1H3 | |
| SCHEMBL6560182 | 0.64 | PPARA (0.48) | GRM2PPARGPPARDPPARA | |
| SCHEMBL7040758 | 0.64 | PPARA (0.64) | PPARGPPARDPPARA | |
| SCHEMBL6559350 | 0.63 | GRM2 (0.40) | GRM2PPARGNR1H2PPARDPPARA | |
| SCHEMBL7819515 | 0.62 | HTR2A (0.39) | POLB | |
| SCHEMBL2363775 | 0.61 | L3MBTL1 (0.50) | POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0882029-B1 | HETEROCYCLIC DERIVATIVES AS ANTIDIABETIC AND ANTIOBESITY AGENTS | MERCK & CO INC (US) | 2003-04-02 | — | — | EP | claimed |
| EP-0882029-B1 | HETEROCYCLIC DERIVATIVES AS ANTIDIABETIC AND ANTIOBESITY AGENTS | MERCK & CO INC (US) | 2003-04-02 | — | — | EP | disclosed |
| US-6090836-A | DIETETICS; ADJUSTMENT OF TRIGLYCERIDE CONCENTRATION | MERCK & CO., INC. (US) | 2000-07-18 | — | — | US | disclosed |