Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Nitric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.52 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.52 |
| ▸ | CA5A | P35218 | 1/20 | 0.40 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.40 |
| ▸ | F2 | P00734 | 2/20 | 0.33 |
| ▸ | PRSS1 | P07477 | 4/20 | 0.31 |
| ▸ | NOS3 | P29474 | 1/20 | 0.30 |
| ▸ | NOS1 | P29475 | 1/20 | 0.30 |
| ▸ | NOS2 | P35228 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Nitric Acid SCHEMBL9701171 | 0.84 | SPHK2 (0.58) | SPHK2SPHK1CA5ACA5BNOS3 | |
| SCHEMBL8068947 | 0.81 | ALDH1A1 (0.43) | SPHK2SPHK1F2 | |
| SCHEMBL31541186 | 0.81 | SPHK2 (0.72) | SPHK2SPHK1F2PRSS1 | |
| SCHEMBL17747405 | 0.81 | SPHK2 (0.72) | SPHK2SPHK1F2PRSS1 | |
| SCHEMBL11154443 | 0.81 | SPHK2 (0.72) | SPHK2SPHK1F2PRSS1 | |
| SCHEMBL23668354 | 0.81 | SPHK2 (0.72) | SPHK2SPHK1F2PRSS1 | |
| SCHEMBL31541184 | 0.81 | SPHK2 (0.72) | SPHK2SPHK1F2PRSS1 | |
| SCHEMBL7851689 | 0.78 | SPHK2 (0.67) | SPHK2SPHK1F2PRSS1 | |
| SCHEMBL16302603 | 0.76 | SPHK2 (0.59) | SPHK2SPHK1F2 | |
| SCHEMBL19557855 | 0.76 | SPHK2 (0.59) | SPHK2SPHK1F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040231770-A1 | Gas-generating substances | DELPHI TECHNOLOGIES, INC. | 2004-11-25 | — | — | US | disclosed |