Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 6/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 4/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 7/20 | 0.36 |
| ▸ | MIF | P14174 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7038828 | 0.91 | PDE5A (0.40) | PDE5APDE3AADORA1PDE4BMIF | |
| SCHEMBL7037894 | 0.89 | PDE5A (0.41) | PDE5APDE3AADORA1PDE4BMIF | |
| SCHEMBL7040393 | 0.85 | PDE5A (0.44) | PDE5APDE3AADORA1PDE4BMIF | |
| SCHEMBL7038848 | 0.84 | PDE5A (0.43) | PDE5APDE3AADORA1PDE4BMIF | |
| SCHEMBL7033831 | 0.83 | PDE5A (0.44) | PDE5APDE3AADORA1PDE4BMIF | |
| SCHEMBL7194693 | 0.81 | PDE5A (0.41) | PDE5APDE3AADORA1PDE4BTP53 | |
| SCHEMBL7194688 | 0.81 | PDE5A (0.41) | PDE5APDE3AADORA1PDE4BTP53 | |
| SCHEMBL7148863 | 0.80 | PDE4B (0.40) | PDE5APDE3AADORA1PDE4BHRH3 | |
| SCHEMBL7036668 | 0.80 | PDE4B (0.40) | PDE5APDE3AADORA1PDE4BHRH3 | |
| SCHEMBL7041201 | 0.79 | PDE4B (0.40) | PDE5APDE3AADORA1PDE4BHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003004494-A1 | PYRIDAZINONE COMPOUND AS ADENOSINE ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-01-16 | — | — | WO | disclosed |