Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 5/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | GLA | P06280 | 2/20 | 0.38 |
| ▸ | RET | P07949 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7194693 | 1.00 | PDE5A (0.41) | PDE5APDE3APDE4BKDM4EALDH1A1 | |
| SCHEMBL7040393 | 0.86 | PDE5A (0.44) | PDE5APDE3APDE4BALDH1A1ADORA1 | |
| SCHEMBL7040647 | 0.86 | MAPT (0.38) | PDE5APDE3APDE4BKDM4EALDH1A1 | |
| SCHEMBL7038848 | 0.85 | PDE5A (0.43) | PDE5APDE3APDE4BALDH1A1ADORA1 | |
| SCHEMBL7034421 | 0.84 | PDE4B (0.40) | PDE5APDE3APDE4BALDH1A1ADORA1 | |
| SCHEMBL7109021 | 0.84 | PDE5A (0.36) | PDE5APDE3APDE4BKDM4EALDH1A1 | |
| SCHEMBL7039977 | 0.83 | MAPT (0.38) | PDE5APDE3APDE4BKDM4EALDH1A1 | |
| SCHEMBL7039975 | 0.83 | MAPT (0.38) | PDE5APDE3APDE4BKDM4EALDH1A1 | |
| SCHEMBL7037894 | 0.83 | PDE5A (0.41) | PDE5APDE3APDE4BALDH1A1ADORA1 | |
| SCHEMBL7041467 | 0.81 | PDE5A (0.40) | PDE5APDE3APDE4BALDH1A1ADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003004494-A1 | PYRIDAZINONE COMPOUND AS ADENOSINE ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-01-16 | — | — | WO | disclosed |