Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 15/20 | 0.65 |
| ▸ | PPARA | Q07869 | 13/20 | 0.65 |
| ▸ | NR1H2 | P55055 | 12/20 | 0.65 |
| ▸ | NR1H3 | Q13133 | 12/20 | 0.65 |
| ▸ | PPARD | Q03181 | 12/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8003777 | 0.92 | PPARG (0.76) | PPARGPPARANR1H2NR1H3PPARD | |
| SCHEMBL7044450 | 0.86 | NR1H3 (0.84) | PPARGPPARANR1H2NR1H3PPARD | |
| SCHEMBL7042314 | 0.83 | NR1H3 (0.72) | PPARGPPARANR1H2NR1H3PPARD | |
| SCHEMBL7046234 | 0.80 | PPARD (0.62) | PPARGPPARANR1H2NR1H3PPARD | |
| SCHEMBL7044850 | 0.80 | PPARA (0.69) | PPARGPPARANR1H2NR1H3PPARD | |
| SCHEMBL7039142 | 0.80 | PPARA (0.75) | PPARGPPARANR1H2NR1H3PPARD | |
| SCHEMBL5338721 | 0.79 | PPARA (0.79) | PPARGPPARANR1H2NR1H3PPARD | |
| SCHEMBL7046443 | 0.79 | PPARD (0.60) | PPARGPPARANR1H2NR1H3PPARD | |
| SCHEMBL29816268 | 0.79 | PPARD (1.00) | PPARGPPARANR1H2NR1H3PPARD | |
| SCHEMBL2898933 | 0.79 | PPARD (1.00) | PPARGPPARANR1H2NR1H3PPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0882029-B1 | HETEROCYCLIC DERIVATIVES AS ANTIDIABETIC AND ANTIOBESITY AGENTS | MERCK & CO INC (US) | 2003-04-02 | — | — | EP | claimed |