Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC2 | Q92769 | 3/20 | 0.58 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.57 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.55 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.55 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.54 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.54 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.52 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.50 |
| ▸ | KDM1A | O60341 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3653038 | 0.93 | HDAC3 (0.62) | HDAC2HDAC1HDAC3NCOR2HDAC8 | |
| SCHEMBL7046517 | 0.89 | ABCB1 (0.52) | HDAC2HDAC1HDAC3NCOR2HDAC8 | |
| SCHEMBL5794325 | 0.87 | HDAC3 (0.67) | HDAC2HDAC1HDAC3NCOR2HDAC8 | |
| SCHEMBL9191952 | 0.85 | HDAC3 (0.71) | HDAC2HDAC1HDAC3NCOR2HDAC8 | |
| SCHEMBL6763786 | 0.83 | HDAC3 (0.74) | HDAC2HDAC1HDAC3NCOR2HDAC8 | |
| SCHEMBL23710387 | 0.81 | HDAC3 (0.54) | HDAC2HDAC1HDAC3NCOR2HDAC8 | |
| SCHEMBL1232934 | 0.81 | TRPV1 (0.55) | HDAC2HDAC1HDAC3NCOR2HDAC8 | |
| SCHEMBL14619461 | 0.81 | MEN1 (0.57) | FFAR1NPC1RAB9A | |
| SCHEMBL13087244 | 0.80 | HDAC3 (0.66) | HDAC2HDAC1HDAC3NCOR2HDAC8 | |
| SCHEMBL9191954 | 0.80 | HDAC3 (0.66) | HDAC2HDAC1HDAC3NCOR2HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0874808-B1 | BIPHENYL HYDROXAMATE INHIBITORS OF MATRIX METALLOPROTEINASES | ABBOTT LAB (US) | 2003-04-09 | — | — | EP | disclosed |
| EP-0874808-A1 | BIPHENYL HYDROXAMATE INHIBITORS OF MATRIX METALLOPROTEINASES | Abbott Laboratories (US) | 1998-11-04 | — | — | EP | disclosed |
| US-5665777-A | ANTIINFLAMMATORY AGENTS | ABBOTT LABORATORIES (US) | 1997-09-09 | — | — | US | disclosed |
| WO-1997018188-A1 | BIPHENYL HYDROXAMATE INHIBITORS OF MATRIX METALLOPROTEINASES | ABBOTT LABORATORIES (US) | 1997-05-22 | — | — | WO | disclosed |