Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7038476 | 0.96 | MEN1 (0.40) | MEN1KMT2APARP1ALDH1A1HTT | |
| SCHEMBL7038533 | 0.89 | PARP1 (0.47) | PARP1ALDH1A1DRD2L3MBTL1 | |
| SCHEMBL7043633 | 0.87 | PARP1 (0.41) | MEN1KMT2APARP1ALDH1A1CYP1A2 | |
| SCHEMBL7043857 | 0.86 | ALDH1A1 (0.43) | MEN1KMT2APARP1ALDH1A1 | |
| SCHEMBL5619750 | 0.86 | PARP1 (0.52) | MEN1KMT2APARP1ALDH1A1HTT | |
| SCHEMBL7039979 | 0.85 | PARP1 (0.50) | MEN1KMT2APARP1DRD2L3MBTL1 | |
| SCHEMBL7040070 | 0.85 | NPSR1 (0.40) | MEN1KMT2APARP1ALDH1A1 | |
| SCHEMBL7047366 | 0.85 | NPSR1 (0.40) | MEN1KMT2APARP1ALDH1A1 | |
| SCHEMBL7041749 | 0.85 | ALDH1A1 (0.44) | MEN1KMT2APARP1ALDH1A1SMN1; SMN2 | |
| SCHEMBL7043577 | 0.84 | ALDH1A1 (0.44) | MEN1KMT2APARP1ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1133477-B1 | SUBSTITUTED BENZIMIDAZOLES AND THEIR USE AS PARP INHIBITORS | ABBOTT GMBH & CO KG (DE) | 2004-02-18 | — | — | EP | disclosed |