Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | NOS2 | P35228 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6120106 | 0.83 | SMN1; SMN2 (0.56) | SMN1; SMN2MEN1GAAKMT2AALDH1A1 | |
| SCHEMBL1162993 | 0.80 | SMN1; SMN2 (0.66) | SMN1; SMN2MEN1GAAKMT2AALDH1A1 | |
| SCHEMBL2184519 | 0.78 | SMN1; SMN2 (0.64) | SMN1; SMN2MEN1GAAKMT2AALDH1A1 | |
| SCHEMBL6076413 | 0.78 | SMN1; SMN2 (0.64) | SMN1; SMN2MEN1GAAKMT2AALDH1A1 | |
| SCHEMBL3243742 | 0.77 | SMN1; SMN2 (0.62) | SMN1; SMN2MEN1GAAKMT2AALDH1A1 | |
| SCHEMBL21745741 | 0.77 | SMN1; SMN2 (0.62) | SMN1; SMN2MEN1GAAKMT2AALDH1A1 | |
| SCHEMBL8872516 | 0.77 | SMN1; SMN2 (0.62) | SMN1; SMN2MEN1GAAKMT2AALDH1A1 | |
| SCHEMBL27574237 | 0.76 | SMN1; SMN2 (0.68) | SMN1; SMN2MEN1GAAKMT2ALMNA | |
| SCHEMBL9703145 | 0.76 | SMN1; SMN2 (0.54) | SMN1; SMN2MEN1GAAKMT2AALDH1A1 | |
| SCHEMBL16166404 | 0.76 | SMN1; SMN2 (0.61) | SMN1; SMN2MEN1GAAKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0977735-B1 | VITRONECTIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2003-03-26 | — | — | EP | disclosed |
| US-6191304-B1 | REDUCTION OF AN ALKYL 3-ALKYLOXY-11-OXO-10,11-DIHYDRO-5H-DIBENZO(A,D)CYCLOHEPTEN-10-ACETATE BY HYDROGENOLYSIS USING A PALLADIUM/ACTIVATED CARBON CATALYST; INTERMEDIATES FOR3-((4-AMINOPYRID-2-YL)AMINOALKYLENEOXY) DERIVATIVES | SMITHKLINE BEECHAM CORPORATION | 2001-02-20 | — | — | US | disclosed |
| US-6069158-A | Vitronectin receptor antagonists | SMITHKLINE BEECHAM CORPORATION (US) | 2000-05-30 | — | — | US | disclosed |
| EP-0977735-A4 | VITRONECTIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2000-04-05 | — | — | EP | disclosed |
| EP-0977735-A1 | VITRONECTIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-02-09 | — | — | EP | disclosed |
| WO-1998030542-A1 | VITRONECTIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1998-07-16 | — | — | WO | disclosed |