Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.54 |
| ▸ | NPC1 | O15118 | 3/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | COMT | P21964 | 2/20 | 0.47 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.47 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.47 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.47 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.47 |
| ▸ | TTR | P02766 | 1/20 | 0.47 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7046272 | 0.81 | TTR (0.53) | LMNANPC1MAPTMEN1KMT2A | |
| SCHEMBL7045653 | 0.81 | TTR (0.67) | LMNANPC1MAPTMEN1KMT2A | |
| SCHEMBL7046444 | 0.81 | TTR (0.51) | LMNANPC1MAPTMEN1KMT2A | |
| SCHEMBL7048659 | 0.79 | TTR (0.52) | LMNAMAPTMEN1KMT2AGAA | |
| SCHEMBL7046543 | 0.79 | TTR (0.58) | LMNANPC1MAPTMEN1KMT2A | |
| Nebicapone SCHEMBL29379610 | 0.78 | TTR (0.56) | LMNAMAPTMEN1KMT2AHPGD | |
| Nebicapone SCHEMBL132167 | 0.78 | TTR (0.56) | LMNAMAPTMEN1KMT2AHPGD | |
| SCHEMBL7048078 | 0.78 | TTR (0.52) | LMNANPC1MAPTMEN1KMT2A | |
| SCHEMBL7046913 | 0.78 | TTR (0.50) | LMNANPC1MAPTMEN1KMT2A | |
| SCHEMBL7046492 | 0.78 | TTR (0.55) | LMNAMAPTMEN1KMT2AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1010688-B1 | Substituted 2-phenyl-1-(3,4-dihydroxy-5-nitrophenyl)-1-ethanones, their use in the treatment of some central and peripheral nervous system disorders and pharmaceutical compositions containing them | PORTELA & CA SA (PT) | 2003-04-09 | — | — | EP | disclosed |
| US-6512136-B1 | Hypotensive, antiedemic agents; gastrointestinal disorders; Parkinson*s disease treatment | PORTELA & C.A., S.A. (PT) | 2003-01-28 | — | — | US | disclosed |
| EP-1010688-A1 | Substituted 2-phenyl-1-(3,4-dihydroxy-5-nitrophenyl)-1-ethanones, their use in the treatment of some central and peripheral nervous system disorders and pharmaceutical compositions containing them | Portela & Ca., S.A. (PT) | 2000-06-21 | — | — | EP | disclosed |