Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR | P02766 | 7/20 | 0.55 |
| ▸ | COMT | P21964 | 3/20 | 0.55 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.55 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.55 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.55 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.55 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.55 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.55 |
| ▸ | PGR | P06401 | 1/20 | 0.55 |
| ▸ | HTR1A | P08908 | 1/20 | 0.55 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.55 |
| ▸ | RARB | P10826 | 1/20 | 0.55 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.55 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.55 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.55 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.55 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.55 |
| ▸ | KLF10 | Q13118 | 1/20 | 0.55 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7045653 | 0.86 | TTR (0.67) | TTRCOMTGPR35ABCC3ABCC4 | |
| Nebicapone SCHEMBL29379610 | 0.85 | TTR (0.56) | TTRCOMTGPR35ABCC3ABCC4 | |
| Nebicapone SCHEMBL132167 | 0.85 | TTR (0.56) | TTRCOMTGPR35ABCC3ABCC4 | |
| SCHEMBL7046272 | 0.84 | TTR (0.53) | TTRCOMTGPR35ABCC3ABCC4 | |
| SCHEMBL7048474 | 0.82 | MAOA (0.60) | TTRCOMTGPR35ABCC3ABCC4 | |
| SCHEMBL7046444 | 0.80 | TTR (0.51) | TTRCOMTGPR35ABCC3ABCC4 | |
| SCHEMBL7046913 | 0.80 | TTR (0.50) | TTRCOMTGPR35ABCC3ABCC4 | |
| SCHEMBL7198182 | 0.79 | CRHBP (0.52) | TTRCOMTGPR35ABCC3ABCC4 | |
| SCHEMBL7045411 | 0.79 | TTR (0.53) | TTRCOMTGPR35ABCC3ABCC4 | |
| SCHEMBL7044301 | 0.78 | LMNA (0.54) | TTRCOMTGPR35ABCC3ABCC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1010688-B1 | Substituted 2-phenyl-1-(3,4-dihydroxy-5-nitrophenyl)-1-ethanones, their use in the treatment of some central and peripheral nervous system disorders and pharmaceutical compositions containing them | PORTELA & CA SA (PT) | 2003-04-09 | — | — | EP | disclosed |
| US-6512136-B1 | Hypotensive, antiedemic agents; gastrointestinal disorders; Parkinson*s disease treatment | PORTELA & C.A., S.A. (PT) | 2003-01-28 | — | — | US | disclosed |
| EP-1010688-A1 | Substituted 2-phenyl-1-(3,4-dihydroxy-5-nitrophenyl)-1-ethanones, their use in the treatment of some central and peripheral nervous system disorders and pharmaceutical compositions containing them | Portela & Ca., S.A. (PT) | 2000-06-21 | — | — | EP | disclosed |