Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NCF1 | P14598 | 6/20 | 0.52 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.40 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | HTR6 | P50406 | 1/20 | 0.40 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5517334 | 0.99 | NCF1 (0.50) | NCF1FFAR1L3MBTL1ATMADRB2 | |
| SCHEMBL5517271 | 0.89 | NCF1 (0.42) | NCF1FFAR1HTR6 | |
| SCHEMBL5531932 | 0.89 | FFAR1 (0.43) | NCF1FFAR1HTR6 | |
| SCHEMBL5518640 | 0.88 | NCF1 (0.44) | NCF1ADRB2ADRB1ALDH1A1HTR6 | |
| SCHEMBL5519494 | 0.87 | NCF1 (0.42) | NCF1ADRB2ADRB1ALDH1A1HTR6 | |
| SCHEMBL5519063 | 0.87 | NCF1 (0.42) | NCF1 | |
| SCHEMBL5522244 | 0.87 | NCF1 (0.42) | NCF1L3MBTL1ALDH1A1HTR6PKM | |
| SCHEMBL5513324 | 0.87 | NCF1 (0.42) | NCF1PKM | |
| SCHEMBL5514139 | 0.86 | NCF1 (0.55) | NCF1L3MBTL1ATMADRB2ADRB1 | |
| SCHEMBL5522907 | 0.85 | NCF1 (0.47) | NCF1FFAR1L3MBTL1ADRB2ADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1432421-A1 | QUINOLINE DERIVATIVES AS NEUROPEPTIDE Y ANTAGONISTS | F. Hoffmann-La Roche AG (CH) | 2004-06-30 | — | — | EP | disclosed |
| WO-2003028726-A1 | QUINOLINE DERIVATIVES AS NEUROPEPTIDE Y ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-04-10 | — | — | WO | disclosed |