Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 2/20 | 0.41 |
| ▸ | HTR2A | P28223 | 4/20 | 0.36 |
| ▸ | DRD1 | P21728 | 4/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 4/20 | 0.35 |
| ▸ | HTR1A | P08908 | 3/20 | 0.34 |
| ▸ | BRD4 | O60885 | 2/20 | 0.33 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | HRH1 | P35367 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.33 |
| ▸ | OGFRL1 | Q5TC84 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7042328 | 0.90 | PARP1 (0.43) | PARP1HTR2ADRD1SCN9ADRD2 | |
| SCHEMBL7041865 | 0.90 | PARP1 (0.43) | PARP1HTR2ADRD1SCN9ADRD2 | |
| SCHEMBL7045984 | 0.90 | PARP1 (0.44) | PARP1HTR2ADRD1SCN9ADRD2 | |
| SCHEMBL7044198 | 0.89 | PARP1 (0.42) | PARP1HTR2ADRD1SCN9ADRD2 | |
| SCHEMBL7045077 | 0.88 | PARP1 (0.44) | PARP1HTR2ADRD1SCN9ADRD2 | |
| SCHEMBL5622204 | 0.86 | PARP1 (0.55) | PARP1HTR1A | |
| SCHEMBL7041326 | 0.85 | PARP1 (0.43) | PARP1HTR2ASCN9ADRD2CYP2D6 | |
| SCHEMBL7043521 | 0.85 | PARP1 (0.45) | PARP1DRD2CYP2D6HRH1KCNH2 | |
| SCHEMBL7041972 | 0.85 | PARP1 (0.55) | PARP1DRD2BRD4CREBBPHRH1 | |
| SCHEMBL7039404 | 0.84 | PARP1 (0.49) | PARP1DRD2BRD4CREBBPCYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1133477-B1 | SUBSTITUTED BENZIMIDAZOLES AND THEIR USE AS PARP INHIBITORS | ABBOTT GMBH & CO KG (DE) | 2004-02-18 | — | — | EP | disclosed |
| EP-1133477-A1 | SUBSTITUTED BENZIMIDAZOLES AND THEIR USE AS PARP INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2001-09-19 | — | — | EP | disclosed |
| WO-2000032579-A1 | SUBSTITUTED BENZIMIDAZOLES AND THEIR USE AS PARP INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2000-06-08 | — | — | WO | disclosed |