Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 8/20 | 0.55 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.43 |
| ▸ | HRH1 | P35367 | 9/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 2/20 | 0.38 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7039404 | 0.95 | PARP1 (0.49) | PARP1PARP2HRH1DRD2BRD4 | |
| SCHEMBL7043521 | 0.91 | PARP1 (0.45) | PARP1HRH1DRD2 | |
| SCHEMBL7040941 | 0.90 | PARP1 (0.57) | PARP1PARP2HRH1DRD2BRD4 | |
| SCHEMBL7043682 | 0.90 | PARP1 (0.57) | PARP1PARP2HRH1DRD2BRD4 | |
| SCHEMBL7043338 | 0.89 | PARP1 (0.59) | PARP1PARP2HRH1DRD2BRD4 | |
| SCHEMBL7046731 | 0.89 | PARP1 (0.56) | PARP1PARP2HRH1DRD2BRD4 | |
| SCHEMBL7042083 | 0.88 | PARP1 (0.56) | PARP1PARP2HRH1DRD2BRD4 | |
| SCHEMBL7042613 | 0.88 | PARP1 (0.56) | PARP1PARP2HRH1DRD2BRD4 | |
| SCHEMBL7046373 | 0.87 | JAK2 (0.45) | PARP1BRD4CREBBP | |
| SCHEMBL5620553 | 0.86 | PARP1 (0.74) | PARP1PARP2HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1133477-B1 | SUBSTITUTED BENZIMIDAZOLES AND THEIR USE AS PARP INHIBITORS | ABBOTT GMBH & CO KG (DE) | 2004-02-18 | — | — | EP | disclosed |
| EP-1133477-A1 | SUBSTITUTED BENZIMIDAZOLES AND THEIR USE AS PARP INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2001-09-19 | — | — | EP | disclosed |
| WO-2000032579-A1 | SUBSTITUTED BENZIMIDAZOLES AND THEIR USE AS PARP INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2000-06-08 | — | — | WO | disclosed |