Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP3 | O14638 | 9/20 | 0.40 |
| ▸ | ENPP1 | P22413 | 9/20 | 0.40 |
| ▸ | ENPP2 | Q13822 | 6/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5033466 | 1.00 | ENPP3 (0.40) | ENPP3ENPP1ENPP2TRPV1NPC1 | |
| SCHEMBL5040967 | 0.92 | NPC1 (0.46) | ENPP3ENPP1ENPP2TRPV1NPC1 | |
| SCHEMBL5037738 | 0.87 | GRM4 (0.47) | ENPP3ENPP1ENPP2TRPV1NPC1 | |
| SCHEMBL5043133 | 0.86 | NAMPT (0.50) | — | |
| SCHEMBL5042870 | 0.86 | ENPP3 (0.48) | ENPP3ENPP1ENPP2NPC1RAB9A | |
| SCHEMBL5036480 | 0.86 | NPC1 (0.53) | ENPP3ENPP1ENPP2NPC1RAB9A | |
| SCHEMBL5037777 | 0.85 | ENPP3 (0.52) | ENPP3ENPP1ENPP2NPC1RAB9A | |
| SCHEMBL5041053 | 0.85 | NPC1 (0.52) | ENPP3ENPP1ENPP2NPC1RAB9A | |
| SCHEMBL5033714 | 0.85 | NPC1 (0.54) | ENPP3ENPP1ENPP2NPC1RAB9A | |
| SCHEMBL5037862 | 0.85 | NPC1 (0.52) | ENPP3ENPP1ENPP2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1432417-A2 | SUBSTITUTED BENZIMIDAZOLE COMPOUNDS AND THEIR USE FOR THE TREATMENT OF CANCER | Aventis Pharma S.A. (FR) | 2004-06-30 | — | — | EP | disclosed |
| WO-2003028721-A2 | SUBSTITUTED BENZIMIDAZOLE COMPOUNDS AND THEIR USE FOR THE TREATMENT OF CANCER | AVENTIS PHARMA S.A. (FR) | 2003-04-10 | — | — | WO | disclosed |