Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | ENPP3 | O14638 | 2/20 | 0.34 |
| ▸ | ENPP1 | P22413 | 2/20 | 0.34 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.34 |
| ▸ | CDC25B | P30305 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.34 |
| ▸ | CCR8 | P51685 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5033476 | 0.89 | PDE3B (0.44) | MAPTLMNAPDE3BPDE3ASMN1; SMN2 | |
| SCHEMBL5041056 | 0.88 | SMN1; SMN2 (0.44) | SMN1; SMN2ENPP3ENPP1ENPP2 | |
| SCHEMBL5037634 | 0.82 | MAPT (0.45) | MAPTLMNASMN1; SMN2KDM4EUSP2 | |
| SCHEMBL5036062 | 0.81 | MAPT (0.43) | MAPTSMN1; SMN2KDM4EUSP2HSD17B10 | |
| SCHEMBL5033494 | 0.81 | GPR119 (0.44) | MAPTLMNASMN1; SMN2ENPP3ENPP1 | |
| SCHEMBL5036504 | 0.80 | SMN1; SMN2 (0.50) | MAPTSMN1; SMN2USP2ENPP3ENPP1 | |
| SCHEMBL5036013 | 0.79 | SMN1; SMN2 (0.44) | MAPTSMN1; SMN2KDM4EUSP2HSD17B10 | |
| SCHEMBL5033454 | 0.79 | ABL1 (0.46) | SMN1; SMN2ENPP3ENPP1ENPP2BRD4 | |
| SCHEMBL5033793 | 0.79 | SMN1; SMN2 (0.47) | SMN1; SMN2ENPP3ENPP1ENPP2 | |
| SCHEMBL5033727 | 0.78 | SMN1; SMN2 (0.47) | SMN1; SMN2ENPP3ENPP1ENPP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1432417-A2 | SUBSTITUTED BENZIMIDAZOLE COMPOUNDS AND THEIR USE FOR THE TREATMENT OF CANCER | Aventis Pharma S.A. (FR) | 2004-06-30 | — | — | EP | disclosed |
| WO-2003028721-A2 | SUBSTITUTED BENZIMIDAZOLE COMPOUNDS AND THEIR USE FOR THE TREATMENT OF CANCER | AVENTIS PHARMA S.A. (FR) | 2003-04-10 | — | — | WO | disclosed |