Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | LGMN | Q99538 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | CASP1 | P29466 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5036062 | 0.92 | MAPT (0.43) | MAPTALDH1A1HPGDSMN1; SMN2LGMN | |
| SCHEMBL7045219 | 0.90 | MAPT (0.39) | MAPTHPGDSMN1; SMN2POLBLMNA | |
| SCHEMBL5043029 | 0.87 | SMN1; SMN2 (0.45) | SMN1; SMN2POLBTDP1ENPP3ENPP1 | |
| SCHEMBL5037647 | 0.84 | SMN1; SMN2 (0.44) | MAPTSMN1; SMN2KDM4EHSD17B10POLB | |
| SCHEMBL5033476 | 0.84 | PDE3B (0.44) | MAPTALDH1A1SMN1; SMN2KDM4EHSD17B10 | |
| SCHEMBL5035919 | 0.82 | SMN1; SMN2 (0.44) | MAPTSMN1; SMN2POLBTDP1ENPP3 | |
| SCHEMBL5036783 | 0.82 | SMN1; SMN2 (0.44) | MAPTSMN1; SMN2POLBTDP1ENPP3 | |
| SCHEMBL5033793 | 0.82 | SMN1; SMN2 (0.47) | SMN1; SMN2POLBTDP1ENPP3ENPP1 | |
| SCHEMBL5037629 | 0.81 | ABL1 (0.46) | MAPTHPGDSMN1; SMN2POLBLMNA | |
| SCHEMBL5033727 | 0.81 | SMN1; SMN2 (0.47) | SMN1; SMN2POLBTDP1ENPP3ENPP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1432417-A2 | SUBSTITUTED BENZIMIDAZOLE COMPOUNDS AND THEIR USE FOR THE TREATMENT OF CANCER | Aventis Pharma S.A. (FR) | 2004-06-30 | — | — | EP | disclosed |
| WO-2003028721-A2 | SUBSTITUTED BENZIMIDAZOLE COMPOUNDS AND THEIR USE FOR THE TREATMENT OF CANCER | AVENTIS PHARMA S.A. (FR) | 2003-04-10 | — | — | WO | disclosed |