Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | ENPP3 | O14638 | 9/20 | 0.36 |
| ▸ | ENPP1 | P22413 | 8/20 | 0.36 |
| ▸ | ENPP2 | Q13822 | 6/20 | 0.36 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5037629 | 0.91 | ABL1 (0.46) | MAPTABL1SMN1; SMN2LMNAHPGD | |
| SCHEMBL5043029 | 0.91 | SMN1; SMN2 (0.45) | SMN1; SMN2POLBENPP3ENPP1ENPP2 | |
| SCHEMBL7045175 | 0.90 | MAPT (0.43) | MAPTSMN1; SMN2LMNAHPGDPOLB | |
| SCHEMBL5037647 | 0.86 | SMN1; SMN2 (0.44) | MAPTABL1SMN1; SMN2LMNAPOLB | |
| SCHEMBL5033857 | 0.86 | ABL1 (0.47) | MAPTABL1SMN1; SMN2POLBENPP3 | |
| SCHEMBL5033793 | 0.85 | SMN1; SMN2 (0.47) | ABL1SMN1; SMN2POLBENPP3ENPP1 | |
| SCHEMBL5033727 | 0.84 | SMN1; SMN2 (0.47) | ABL1SMN1; SMN2POLBENPP3ENPP1 | |
| SCHEMBL5036783 | 0.84 | SMN1; SMN2 (0.44) | MAPTABL1SMN1; SMN2POLBENPP3 | |
| SCHEMBL5035919 | 0.84 | SMN1; SMN2 (0.44) | MAPTABL1SMN1; SMN2POLBENPP3 | |
| SCHEMBL5036605 | 0.84 | SMN1; SMN2 (0.46) | SMN1; SMN2POLBENPP3ENPP1ENPP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1432417-A2 | SUBSTITUTED BENZIMIDAZOLE COMPOUNDS AND THEIR USE FOR THE TREATMENT OF CANCER | Aventis Pharma S.A. (FR) | 2004-06-30 | — | — | EP | disclosed |
| WO-2003028721-A2 | SUBSTITUTED BENZIMIDAZOLE COMPOUNDS AND THEIR USE FOR THE TREATMENT OF CANCER | AVENTIS PHARMA S.A. (FR) | 2003-04-10 | — | — | WO | disclosed |