Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKACA | P17612 | 1/20 | 0.40 |
| ▸ | CDK8 | P49336 | 1/20 | 0.40 |
| ▸ | GSK3A | P49840 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | PRKX | P51817 | 1/20 | 0.40 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.40 |
| ▸ | PTGFR | P43088 | 1/20 | 0.40 |
| ▸ | CFD | P00746 | 1/20 | 0.38 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.38 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.38 |
| ▸ | CCR5 | P51681 | 4/20 | 0.38 |
| ▸ | PHGDH | O43175 | 1/20 | 0.38 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.37 |
| ▸ | TACR3 | P29371 | 1/20 | 0.37 |
| ▸ | AKT1 | P31749 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3383580 | 1.00 | PRKACA (0.40) | PRKACACDK8GSK3AGSK3BPRKX | |
| SCHEMBL3386255 | 0.90 | PTGFR (0.46) | PTGFRCFDCCR5RPS6KB1WDR91 | |
| SCHEMBL3382787 | 0.85 | CFD (0.40) | PTGFRCFD | |
| SCHEMBL13004626 | 0.85 | PTGFR (0.39) | PRKACACDK8GSK3AGSK3BPRKX | |
| SCHEMBL3386859 | 0.85 | PTGFR (0.39) | PRKACACDK8GSK3AGSK3BPRKX | |
| SCHEMBL3385956 | 0.85 | PTGFR (0.39) | PRKACACDK8GSK3AGSK3BPRKX | |
| SCHEMBL3383891 | 0.80 | JAK2 (0.38) | PTGFRCFD | |
| SCHEMBL3382557 | 0.78 | PTGFR (0.64) | PRKACACDK8GSK3AGSK3BPRKX | |
| SCHEMBL3382579 | 0.78 | PTGFR (0.64) | PRKACACDK8GSK3AGSK3BPRKX | |
| SCHEMBL3382653 | 0.78 | PTGFR (0.64) | PRKACACDK8GSK3AGSK3BPRKX |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1487442-A1 | THIAZOLIDINE CARBOXAMIDE DERIVATIVES AS MODULATORS OF THE PROSTAGLANDIN F RECEPTOR | Applied Research Systems ARS Holding N.V. (AN) | 2004-12-22 | — | — | EP | disclosed |
| WO-2003082278-A1 | THIAZOLIDINE CARBOXAMIDE DERIVATIVES AS MODULATORS OF THE PROSTAGLANDIN F RECEPTOR | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2003-10-09 | — | — | WO | disclosed |