Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 10/20 | 0.50 |
| ▸ | SIRT1 | Q96EB6 | 10/20 | 0.50 |
| ▸ | SIRT3 | Q9NTG7 | 10/20 | 0.50 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.48 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SCN10A | Q9Y5Y9 | 2/20 | 0.43 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.42 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.42 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4477190 | 0.81 | MKNK1 (0.66) | SIRT2SIRT1SIRT3MKNK1MKNK2 | |
| SCHEMBL6151471 | 0.79 | L3MBTL1 (0.60) | ALDH1A1ROCK2ROCK1MEN1KMT2A | |
| SCHEMBL6085720 | 0.77 | SIRT2 (0.53) | SIRT2SIRT1SIRT3MKNK1MKNK2 | |
| SCHEMBL4267075 | 0.76 | MKNK1 (0.49) | SIRT2SIRT1SIRT3MKNK1MKNK2 | |
| SCHEMBL2841794 | 0.75 | SIRT2 (0.54) | SIRT2SIRT1SIRT3MKNK1MKNK2 | |
| SCHEMBL29324585 | 0.74 | SIRT2 (0.48) | SIRT2SIRT1SIRT3MKNK1MKNK2 | |
| SCHEMBL7047330 | 0.74 | FURIN (0.46) | ALDH1A1ROCK2GAAROCK1MEN1 | |
| SCHEMBL8447783 | 0.73 | KMT2A (0.64) | ALDH1A1HTTMEN1KMT2ANPC1 | |
| SCHEMBL5973949 | 0.73 | L3MBTL1 (0.70) | ALDH1A1ROCK2ROCK1MEN1KMT2A | |
| SCHEMBL30239217 | 0.73 | KDM4E (0.70) | SIRT2SIRT1SIRT3MKNK1MKNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003006426-A1 | AROMATIC GUANYLHYDRAZONES AS EFFECTIVE COMPOUNDS AGAINST NEURODISEASES | AXXIMA PHARMACEUTICALS AG (DE) | 2003-01-23 | — | — | WO | claimed |
| WO-2003006426-A1 | AROMATIC GUANYLHYDRAZONES AS EFFECTIVE COMPOUNDS AGAINST NEURODISEASES | AXXIMA PHARMACEUTICALS AG (DE) | 2003-01-23 | — | — | WO | disclosed |