Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | ENPP3 | O14638 | 2/20 | 0.37 |
| ▸ | ENPP1 | P22413 | 2/20 | 0.37 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | NOS1 | P29475 | 1/20 | 0.36 |
| ▸ | NOS2 | P35228 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5037634 | 0.94 | MAPT (0.45) | MAPTLMNAKMT2AKDM4EHTT | |
| SCHEMBL5033420 | 0.87 | SMN1; SMN2 (0.46) | ENPP3ENPP1ENPP2SMN1; SMN2TDP1 | |
| SCHEMBL7044917 | 0.86 | SMN1; SMN2 (0.41) | MAPTENPP3ENPP1ENPP2SMN1; SMN2 | |
| SCHEMBL5033476 | 0.84 | PDE3B (0.44) | MAPTLMNAKDM4EENPP3ENPP1 | |
| SCHEMBL5033734 | 0.83 | SMN1; SMN2 (0.45) | MAPTENPP3ENPP1ENPP2SMN1; SMN2 | |
| SCHEMBL5036004 | 0.83 | SMN1; SMN2 (0.48) | ENPP3ENPP1ENPP2SMN1; SMN2TDP1 | |
| SCHEMBL5042870 | 0.81 | ENPP3 (0.48) | ENPP3ENPP1ENPP2SMN1; SMN2TDP1 | |
| SCHEMBL5037697 | 0.81 | SMN1; SMN2 (0.47) | MAPTENPP3ENPP1ENPP2SMN1; SMN2 | |
| SCHEMBL5042885 | 0.81 | SMN1; SMN2 (0.47) | ENPP3ENPP1ENPP2SMN1; SMN2TDP1 | |
| SCHEMBL5040732 | 0.81 | SMN1; SMN2 (0.42) | MAPTKMT2AENPP3ENPP1ENPP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1432417-A2 | SUBSTITUTED BENZIMIDAZOLE COMPOUNDS AND THEIR USE FOR THE TREATMENT OF CANCER | Aventis Pharma S.A. (FR) | 2004-06-30 | — | — | EP | disclosed |
| WO-2003028721-A2 | SUBSTITUTED BENZIMIDAZOLE COMPOUNDS AND THEIR USE FOR THE TREATMENT OF CANCER | AVENTIS PHARMA S.A. (FR) | 2003-04-10 | — | — | WO | disclosed |