Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.68 |
| ▸ | MEN1 | O00255 | 1/20 | 0.68 |
| ▸ | HCRTR1 | O43613 | 5/20 | 0.49 |
| ▸ | HCRTR2 | O43614 | 5/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | ELANE | P08246 | 2/20 | 0.47 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.45 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.42 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6733910 | 0.93 | KMT2A (0.62) | KMT2AMEN1HCRTR1HCRTR2L3MBTL1 | |
| SCHEMBL6734594 | 0.84 | KMT2A (0.66) | KMT2AMEN1HCRTR1HCRTR2L3MBTL1 | |
| SCHEMBL6733707 | 0.84 | KMT2A (0.54) | KMT2AMEN1HCRTR1HCRTR2L3MBTL1 | |
| SCHEMBL9726979 | 0.81 | KMT2A (1.00) | KMT2AMEN1HCRTR1HCRTR2L3MBTL1 | |
| SCHEMBL6732939 | 0.80 | MEN1 (0.43) | KMT2AMEN1HCRTR1HCRTR2 | |
| SCHEMBL5093540 | 0.80 | KMT2A (0.73) | KMT2AMEN1HCRTR1HCRTR2L3MBTL1 | |
| SCHEMBL7954875 | 0.79 | KMT2A (0.59) | KMT2AMEN1HCRTR1HCRTR2L3MBTL1 | |
| SCHEMBL7954267 | 0.78 | KMT2A (0.54) | KMT2AMEN1HCRTR1HCRTR2L3MBTL1 | |
| SCHEMBL6732110 | 0.78 | KMT2A (0.66) | KMT2AMEN1HCRTR1HCRTR2L3MBTL1 | |
| SCHEMBL19585933 | 0.77 | KMT2A (0.57) | KMT2AMEN1HCRTR1HCRTR2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003007940-A1 | LACTAM AND THIOLACTAM DERIVATIVES AS ANESTHETIC AND CONSCIOUS SEDATION AGENTS | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2003-01-30 | — | — | WO | disclosed |
| US-6066666-A | OPTIONALLY N-SUBSTITUTED 3-MONO- AND DI-SUBSTITUTED 2-PYRROLIDINONES AND THIOLACTAM ANALOGS; TREAT SEIZURES, ANXIETY, AND ENHANCING 4-AMINOBUTYRIC ACID (GABA)-INDUCED CHLORIDE CURRENTS AT GABA RECEPTOR/IONOPHORE COMPLEX | WASHINGTON UNIVERSITY (US) | 2000-05-23 | — | — | US | disclosed |
| US-5776959-A | Anticonvulsant and anxiolytic lactam and thiolactam derivatives | WASHINGTON UNIVERSITY (US) | 1998-07-07 | — | — | US | disclosed |