SCHEMBL7046548

SCHEMBL7046548

CCCCOC(=O)P(O)(O)=S

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.52
ATM Q13315 1/20 0.48
TSHR P16473 5/20 0.45
HPGD P15428 1/20 0.45
HCAR2 Q8TDS4 1/20 0.42
LPAR2 Q9HBW0 3/20 0.42
LPAR3 Q9UBY5 3/20 0.42
NAAA Q02083 1/20 0.42
TDP1 Q9NUW8 1/20 0.41
L3MBTL1 Q9Y468 1/20 0.41
RAD52 P43351 1/20 0.40
NPSR1 Q6W5P4 1/20 0.40
EPHX1 P07099 1/20 0.39
LMNA P02545 1/20 0.39
ESR1 P03372 1/20 0.39
CYP1A2 P05177 1/20 0.39
CYP2D6 P10635 1/20 0.39
MAPK1 P28482 1/20 0.39
CYP2C19 P33261 1/20 0.39
NR1H2 P55055 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8465669 0.80 ALDH1A1 (0.54) ALDH1A1ATMTSHRHPGDHCAR2
Butane SCHEMBL2239751 0.78 ALDH1A1 (0.52) ALDH1A1ATMTSHRHPGDHCAR2
SCHEMBL28783278 0.75 CYP3A4 (0.50) ALDH1A1ATMTSHRHPGDHCAR2
SCHEMBL2073921 0.74
SCHEMBL6739566 0.72 LPAR3 (0.55) ALDH1A1TSHRHCAR2LPAR2LPAR3
Butyl Dimethoxyphosphinecarboxylate Oxide SCHEMBL2240121 0.72 ALDH1A1 (0.50) ALDH1A1ATMTSHRHPGDHCAR2
SCHEMBL6733974 0.72 LPAR3 (0.55) ALDH1A1TSHRHCAR2LPAR2LPAR3
SCHEMBL1408929 0.72 ALDH1A1 (0.50) ALDH1A1ATMTSHRHPGDHCAR2
Disodium Butoxycarbonylphosphonate SCHEMBL11147279 0.72 ALDH1A1 (0.50) ALDH1A1ATMTSHRHPGDHCAR2
SCHEMBL6734330 0.72 LPAR3 (0.55) ALDH1A1TSHRHCAR2LPAR2LPAR3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0792275-B1 IMPROVED ANTIVIRAL PRODRUGS UNIV CALIFORNIA (US) 2004-03-03 EP disclosed
US-6002029-A Antiviral prodrugs CHIMERIX, INC. 1999-12-14 US disclosed
EP-0792275-A4 IMPROVED ANTIVIRAL PRODRUGS UNIV CALIFORNIA (US) 1998-02-25 EP disclosed
US-5696277-A CYTOMEGALOVIRUS, HERPES VIRUS Hostetler, Karl Y. (US) 1997-12-09 US disclosed
EP-0792275-A1 IMPROVED ANTIVIRAL PRODRUGS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 1997-09-03 EP disclosed
WO-1996015132-A1 IMPROVED ANTIVIRAL PRODRUGS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 1996-05-23 WO disclosed