Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H3 | Q13133 | 20/20 | 0.69 |
| ▸ | NR1H2 | P55055 | 18/20 | 0.69 |
| ▸ | PPARD | Q03181 | 13/20 | 0.69 |
| ▸ | PPARA | Q07869 | 11/20 | 0.69 |
| ▸ | PPARG | P37231 | 8/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7042099 | 0.91 | NR1H3 (0.82) | NR1H3NR1H2PPARDPPARAPPARG | |
| SCHEMBL5203759 | 0.90 | PPARD (0.83) | NR1H3NR1H2PPARDPPARAPPARG | |
| SCHEMBL7040637 | 0.85 | PPARA (0.68) | PPARDPPARAPPARG | |
| SCHEMBL7042314 | 0.85 | NR1H3 (0.72) | NR1H3NR1H2PPARDPPARAPPARG | |
| SCHEMBL8006436 | 0.85 | NR1H3 (0.69) | NR1H3NR1H2PPARDPPARAPPARG | |
| SCHEMBL7044517 | 0.84 | PPARD (0.86) | NR1H3NR1H2PPARDPPARAPPARG | |
| SCHEMBL14465301 | 0.83 | PPARG (0.86) | NR1H3NR1H2PPARDPPARAPPARG | |
| SCHEMBL14465278 | 0.82 | PPARD (0.68) | NR1H3NR1H2PPARDPPARAPPARG | |
| SCHEMBL14465277 | 0.81 | NR1H3 (0.62) | NR1H3NR1H2PPARDPPARAPPARG | |
| SCHEMBL14465276 | 0.81 | NR1H3 (0.76) | NR1H3NR1H2PPARDPPARAPPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0882029-B1 | HETEROCYCLIC DERIVATIVES AS ANTIDIABETIC AND ANTIOBESITY AGENTS | MERCK & CO INC (US) | 2003-04-02 | — | — | EP | disclosed |
| US-6090836-A | DIETETICS; ADJUSTMENT OF TRIGLYCERIDE CONCENTRATION | MERCK & CO., INC. (US) | 2000-07-18 | — | — | US | disclosed |
| EP-0882029-A1 | HETEROCYCLIC DERIVATIVES AS ANTIDIABETIC AND ANTIOBESITY AGENTS | Merck & Co., Inc. (US) | 1998-12-09 | — | — | EP | disclosed |
| WO-1997028137-A1 | HETEROCYCLIC DERIVATIVES AS ANTIDIABETIC AND ANTIOBESITY AGENTS | MERCK & CO., INC. (US) | 1997-08-07 | — | — | WO | disclosed |