Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP3 | P08254 | 2/20 | 0.66 |
| ▸ | HDAC1 | Q13547 | 11/20 | 0.64 |
| ▸ | HDAC2 | Q92769 | 8/20 | 0.64 |
| ▸ | MMP13 | P45452 | 2/20 | 0.61 |
| ▸ | MMP1 | P03956 | 1/20 | 0.61 |
| ▸ | MMP2 | P08253 | 1/20 | 0.61 |
| ▸ | MMP9 | P14780 | 1/20 | 0.61 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.57 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.57 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.57 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.57 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.53 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.53 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.53 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.53 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.50 |
| ▸ | MMP12 | P39900 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7043051 | 0.81 | HDAC2 (0.90) | HDAC1HDAC2HDAC6HDAC8HDAC3 | |
| SCHEMBL7046816 | 0.81 | MMP3 (0.92) | MMP3HDAC1HDAC2MMP13MMP1 | |
| SCHEMBL6386979 | 0.79 | MMP3 (1.00) | MMP3HDAC1HDAC2MMP13MMP1 | |
| SCHEMBL6390923 | 0.78 | HDAC1 (1.00) | MMP3HDAC1HDAC2MMP13MMP1 | |
| SCHEMBL4741061 | 0.78 | HDAC1 (1.00) | MMP3HDAC1HDAC2MMP13MMP1 | |
| SCHEMBL17857810 | 0.78 | TSHR (0.72) | MMP3MMP13TSHRHSD17B10MMP12 | |
| SCHEMBL7046517 | 0.78 | ABCB1 (0.52) | MMP3HDAC1HDAC2MMP13HDAC6 | |
| SCHEMBL6138535 | 0.77 | MMP3 (0.64) | MMP3HDAC1HDAC2MMP13MMP1 | |
| SCHEMBL6138747 | 0.77 | MMP3 (0.64) | MMP3HDAC1HDAC2MMP13MMP1 | |
| SCHEMBL1336456 | 0.77 | FFAR1 (0.67) | HDAC1HDAC2MMP13MMP2HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0874808-B1 | BIPHENYL HYDROXAMATE INHIBITORS OF MATRIX METALLOPROTEINASES | ABBOTT LAB (US) | 2003-04-09 | — | — | EP | claimed |
| EP-0874808-A1 | BIPHENYL HYDROXAMATE INHIBITORS OF MATRIX METALLOPROTEINASES | Abbott Laboratories (US) | 1998-11-04 | — | — | EP | claimed |
| WO-1997018188-A1 | BIPHENYL HYDROXAMATE INHIBITORS OF MATRIX METALLOPROTEINASES | ABBOTT LABORATORIES (US) | 1997-05-22 | — | — | WO | claimed |
| EP-0874808-B1 | BIPHENYL HYDROXAMATE INHIBITORS OF MATRIX METALLOPROTEINASES | ABBOTT LAB (US) | 2003-04-09 | — | — | EP | disclosed |
| EP-0874808-A1 | BIPHENYL HYDROXAMATE INHIBITORS OF MATRIX METALLOPROTEINASES | Abbott Laboratories (US) | 1998-11-04 | — | — | EP | disclosed |
| US-5665777-A | ANTIINFLAMMATORY AGENTS | ABBOTT LABORATORIES (US) | 1997-09-09 | — | — | US | disclosed |
| WO-1997018188-A1 | BIPHENYL HYDROXAMATE INHIBITORS OF MATRIX METALLOPROTEINASES | ABBOTT LABORATORIES (US) | 1997-05-22 | — | — | WO | disclosed |