Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 10/20 | 0.51 |
| ▸ | MMP3 | P08254 | 8/20 | 0.51 |
| ▸ | PPARG | P37231 | 2/20 | 0.51 |
| ▸ | PPARA | Q07869 | 2/20 | 0.51 |
| ▸ | MMP13 | P45452 | 6/20 | 0.50 |
| ▸ | MMP1 | P03956 | 5/20 | 0.50 |
| ▸ | MMP9 | P14780 | 5/20 | 0.50 |
| ▸ | MMP7 | P09237 | 4/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.48 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11707781 | 0.95 | GAA (0.49) | MMP2MMP3PPARGPPARAMMP13 | |
| SCHEMBL4748762 | 0.84 | GAA (0.48) | MMP2MMP3MMP13MMP1MMP9 | |
| SCHEMBL667009 | 0.84 | GAA (0.48) | MMP2MMP3MMP13MMP1MMP9 | |
| SCHEMBL7966234 | 0.82 | CYP1A2 (0.71) | PPARGPPARAGAACYP1A2CYP2C9 | |
| SCHEMBL21057155 | 0.80 | GAA (0.59) | MMP2MMP3PPARGPPARAGAA | |
| SCHEMBL2830293 | 0.80 | GAA (0.59) | MMP2MMP3PPARGPPARAGAA | |
| SCHEMBL4277047 | 0.79 | SMN1; SMN2 (0.54) | MMP2MMP3PPARGPPARAMMP13 | |
| SCHEMBL28924876 | 0.79 | MMP2 (0.56) | MMP2MMP3MMP13MMP1MMP9 | |
| SCHEMBL13892893 | 0.78 | MMP2 (0.52) | MMP2MMP3MMP13MMP1MMP9 | |
| SCHEMBL11717212 | 0.77 | GAA (0.45) | MMP2MMP3GAASMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0874808-B1 | BIPHENYL HYDROXAMATE INHIBITORS OF MATRIX METALLOPROTEINASES | ABBOTT LAB (US) | 2003-04-09 | — | — | EP | disclosed |
| EP-0874808-A1 | BIPHENYL HYDROXAMATE INHIBITORS OF MATRIX METALLOPROTEINASES | Abbott Laboratories (US) | 1998-11-04 | — | — | EP | disclosed |
| US-5665777-A | ANTIINFLAMMATORY AGENTS | ABBOTT LABORATORIES (US) | 1997-09-09 | — | — | US | disclosed |
| WO-1997018188-A1 | BIPHENYL HYDROXAMATE INHIBITORS OF MATRIX METALLOPROTEINASES | ABBOTT LABORATORIES (US) | 1997-05-22 | — | — | WO | disclosed |