Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 10/20 | 0.50 |
| ▸ | RAB9A | P51151 | 9/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.50 |
| ▸ | TP53 | P04637 | 5/20 | 0.50 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.46 |
| ▸ | PKM | P14618 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | MITF | O75030 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | CASP3 | P42574 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6453543 | 0.91 | NPC1 (0.46) | NPC1RAB9ASMN1; SMN2TP53MAPT | |
| SCHEMBL6450555 | 0.87 | NPC1 (0.50) | NPC1RAB9ASMN1; SMN2TP53MAPT | |
| SCHEMBL6452535 | 0.86 | CASP3 (0.60) | NPC1RAB9ASMN1; SMN2TP53MAPT | |
| SCHEMBL6454139 | 0.85 | NPC1 (0.47) | NPC1RAB9ASMN1; SMN2TP53MAPT | |
| SCHEMBL7049265 | 0.85 | NPC1 (0.51) | NPC1RAB9ASMN1; SMN2TP53MAPT | |
| SCHEMBL6448952 | 0.83 | TP53 (0.50) | NPC1RAB9ASMN1; SMN2TP53MAPT | |
| SCHEMBL6452697 | 0.83 | NPC1 (0.45) | NPC1RAB9ASMN1; SMN2TP53MAPT | |
| SCHEMBL6449934 | 0.81 | ACACB (0.42) | NPC1RAB9ASMN1; SMN2TP53MAPT | |
| SCHEMBL6449987 | 0.81 | MAPT (0.46) | NPC1RAB9ASMN1; SMN2TP53MAPT | |
| SCHEMBL6448673 | 0.81 | NPC1 (0.51) | NPC1RAB9ASMN1; SMN2TP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004110351-A2 | HETEROCYCLIC COMPOUNDS FOR TREATING HEPATITIS C VIRUS | ANADYS PHARMACEUTICALS, INC. (US) | 2004-12-23 | — | — | WO | disclosed |