Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | CASR | P41180 | 2/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.37 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.37 |
| ▸ | TUBB | P07437 | 1/20 | 0.37 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.37 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.37 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.37 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.37 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.37 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.37 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.37 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.37 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5036624 | 0.94 | TSHR (0.43) | TSHRKDM4EALDH1A1GLAGAA | |
| SCHEMBL5040832 | 0.91 | SMN1; SMN2 (0.42) | ENPP3ENPP1ENPP2SMN1; SMN2ACR | |
| SCHEMBL5033529 | 0.90 | JAK1 (0.40) | TSHRALDH1A1GLAJAK1TUBB4A | |
| SCHEMBL5042839 | 0.88 | ENPP3 (0.44) | ENPP3ENPP1ENPP2SMN1; SMN2 | |
| SCHEMBL5033487 | 0.87 | ENPP3 (0.45) | ENPP3ENPP1ENPP2SMN1; SMN2 | |
| SCHEMBL5036324 | 0.86 | SMN1; SMN2 (0.41) | ENPP3ENPP1ENPP2MAPTSMN1; SMN2 | |
| SCHEMBL5040962 | 0.86 | TSHR (0.45) | TSHRKDM4EALDH1A1GLAGAA | |
| SCHEMBL7049581 | 0.84 | ENPP3 (0.43) | ENPP3ENPP1ENPP2SMN1; SMN2 | |
| SCHEMBL5036884 | 0.84 | SMN1; SMN2 (0.43) | ENPP3ENPP1ENPP2SMN1; SMN2 | |
| SCHEMBL5037583 | 0.83 | ENPP3 (0.43) | ENPP3ENPP1ENPP2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1432417-A2 | SUBSTITUTED BENZIMIDAZOLE COMPOUNDS AND THEIR USE FOR THE TREATMENT OF CANCER | Aventis Pharma S.A. (FR) | 2004-06-30 | — | — | EP | disclosed |
| WO-2003028721-A2 | SUBSTITUTED BENZIMIDAZOLE COMPOUNDS AND THEIR USE FOR THE TREATMENT OF CANCER | AVENTIS PHARMA S.A. (FR) | 2003-04-10 | — | — | WO | disclosed |