SCHEMBL7048656

SCHEMBL7048656

Oc1ccc2c(c1)O[C@H](c1ccccc1)CC2O

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP19A1 P11511 8/20 0.60
MAOA P21397 1/20 0.54
MAOB P27338 1/20 0.54
PSMB5 P28074 1/20 0.54
AR P10275 1/20 0.50
CYP1A1 P04798 1/20 0.45
CYP1A2 P05177 1/20 0.45
CYP1B1 Q16678 1/20 0.45
MEN1 O00255 1/20 0.45
CYP3A4 P08684 1/20 0.45
CYP2D6 P10635 1/20 0.45
MAPT P10636 1/20 0.45
CYP2C9 P11712 1/20 0.45
CYP2C19 P33261 1/20 0.45
KMT2A Q03164 1/20 0.45
HSD17B10 Q99714 1/20 0.45
ESR2 Q92731 2/20 0.44
TUBB4A P04350 1/20 0.44
TUBB P07437 1/20 0.44
YES1 P07947 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1933778 1.00 CYP19A1 (0.60) CYP19A1MAOAMAOBPSMB5AR
SCHEMBL4365834 0.88 AR (0.54) CYP19A1MAOAMAOBPSMB5AR
SCHEMBL5744717 0.84 AR (0.52) CYP19A1MAOAMAOBPSMB5AR
SCHEMBL1933397 0.84 CYP19A1 (0.44) CYP19A1MAOAMAOBARMEN1
SCHEMBL10365101 0.83 CYP19A1 (0.53) CYP19A1MAOAMAOBPSMB5AR
SCHEMBL30064231 0.82 CYP19A1 (0.45) CYP19A1MAOAMAOBPSMB5AR
SCHEMBL1267388 0.82 CYP19A1 (0.45) CYP19A1MAOAMAOBPSMB5AR
SCHEMBL380283 0.82 CYP19A1 (0.45) CYP19A1MAOAMAOBPSMB5AR
SCHEMBL25567835 0.81 CYP3A4 (0.50) CYP19A1MAOAMAOBPSMB5AR
SCHEMBL4367671 0.81 ESR1 (0.51) CYP19A1ARCYP3A4ESR2ESR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2003013554-A2 AROMATASE INHIBITORS FROM BROUSSONETIA PAPYRIFERA THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) 2003-02-20 WO disclosed