Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 13/20 | 0.42 |
| ▸ | JAK1 | P23458 | 12/20 | 0.42 |
| ▸ | JAK2 | O60674 | 11/20 | 0.42 |
| ▸ | TYK2 | P29597 | 11/20 | 0.42 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.37 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.37 |
| ▸ | CLCN2 | P51788 | 1/20 | 0.37 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2309272 | 0.86 | PTK2 (0.41) | JAK3JAK1JAK2TYK2PTK2 | |
| SCHEMBL704871 | 0.82 | JAK3 (0.42) | JAK3JAK1JAK2TYK2PTK2 | |
| SCHEMBL691660 | 0.78 | MAPK3 (0.60) | JAK1JAK2TYK2PTK2MAPK8 | |
| SCHEMBL1292972 | 0.78 | PTK2 (0.64) | JAK3JAK1JAK2TYK2PTK2 | |
| SCHEMBL691696 | 0.77 | PTK2 (0.50) | JAK3JAK1JAK2TYK2PTK2 | |
| SCHEMBL21587937 | 0.75 | IGF1R (0.37) | JAK1JAK2TYK2MAPK14MAPK3 | |
| SCHEMBL691689 | 0.75 | MAPK1 (0.47) | JAK1JAK2TYK2MAPK10MAPK3 | |
| SCHEMBL700926 | 0.74 | GAA (0.37) | JAK3JAK1JAK2TYK2PTK2 | |
| SCHEMBL691560 | 0.74 | MAPK1 (0.48) | JAK1JAK2TYK2PTK2MAPK8 | |
| SCHEMBL29127270 | 0.73 | JAK2 (0.42) | JAK3JAK1JAK2TYK2MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2421537-A1 | PYRAZOLYLAMINOPYRIDINES AS INHIBITORS OF FAK | GlaxoSmithKline LLC (US) | 2012-02-29 | — | — | EP | disclosed |
| WO-2010062578-A1 | PYRAZOLYLAMINOPYRIDINES AS INHIBITORS OF FAK | GLAXOSMITHKLINE LLC (US) | 2010-06-03 | — | — | WO | disclosed |