Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES1 | P23141 | 10/20 | 0.65 |
| ▸ | TGM2 | P21980 | 2/20 | 0.40 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.36 |
| ▸ | BCHE | P06276 | 2/20 | 0.34 |
| ▸ | MAOA | P21397 | 3/20 | 0.34 |
| ▸ | MAOB | P27338 | 3/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | NSD2 | O96028 | 1/20 | 0.33 |
| ▸ | DAO | P14920 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7049842 | 1.00 | CES1 (0.65) | CES1TGM2DNMT1BCHEMAOA | |
| SCHEMBL6316990 | 0.89 | CES1 (0.58) | CES1TGM2LRRK2LMNAMAPT | |
| SCHEMBL7052285 | 0.86 | CES1 (0.65) | CES1TGM2DNMT1BCHEMAOA | |
| SCHEMBL7052288 | 0.86 | CES1 (0.65) | CES1TGM2DNMT1BCHEMAOA | |
| SCHEMBL7051496 | 0.84 | CES1 (0.45) | CES1TGM2DNMT1BCHEKDR | |
| SCHEMBL7051497 | 0.84 | CES1 (0.45) | CES1TGM2DNMT1BCHEKDR | |
| SCHEMBL7054937 | 0.79 | CES1 (0.49) | CES1TGM2BCHEMAOAMAOB | |
| SCHEMBL7054935 | 0.79 | CES1 (0.49) | CES1TGM2BCHEMAOAMAOB | |
| SCHEMBL734206 | 0.79 | CES1 (1.00) | CES1TGM2DNMT1BCHEMAOA | |
| SCHEMBL7050695 | 0.77 | CES1 (0.53) | CES1TGM2BCHEMAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0706396-B1 | 1,2,3,4-TETRAHYDROQUINOLINE-2,3,4-TRIONE-3 OR 4-OXIMES AND USE | OREGON STATE (US) | 2003-05-02 | — | — | EP | disclosed |
| US-5652368-A | NERVOUS SYSTEM DISORDERS, ALZHEIMER'S DISEASE | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1997-07-29 | — | — | US | disclosed |
| US-5475007-A | Preventing convulsions | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1995-12-12 | — | — | US | disclosed |