Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL61954 | 0.88 | HPGD (0.53) | — | |
| Bromide SCHEMBL22366420 | 0.85 | CHRM2 (0.48) | CHRM2 | |
| SCHEMBL22598635 | 0.83 | — | — | |
| Bromide SCHEMBL22366445 | 0.78 | CHRM2 (0.44) | CHRM2 | |
| Bromide SCHEMBL22366474 | 0.77 | RPS6KA2 (0.51) | — | |
| Bromide SCHEMBL22366400 | 0.77 | HPGD (0.46) | — | |
| SCHEMBL6790333 | 0.76 | TDP1 (0.71) | CHRM2 | |
| SCHEMBL4351612 | 0.76 | TDP1 (0.66) | CHRM2 | |
| Bromide SCHEMBL22366456 | 0.75 | BCHE (0.53) | — | |
| Bromide SCHEMBL22366418 | 0.75 | MAOB (0.46) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1019722-B1 | POLYMERIC FLUOROPHORES ENHANCED BY MOIETIES PROVIDING A HYDROPHOBIC AND CONFORMATIONALLY RESTRICTIVE MICROENVIRONMENT | ABBOTT LAB (US) | 2003-04-09 | — | — | EP | disclosed |
| EP-1019722-A1 | POLYMERIC FLUOROPHORES ENHANCED BY MOIETIES PROVIDING A HYDROPHOBIC AND CONFORMATIONALLY RESTRICTIVE MICROENVIRONMENT | Abbott Laboratories (US) | 2000-07-19 | — | — | EP | disclosed |
| US-5994143-A | FLUORESCENT CONJUGATES SUITABLE FOR USE IN FLOW CYTOMETRY AND OTHER BIOLOGICAL APPLICATIONS; THE FLUORESCENT CONJUGATES COMPRISE AN ANTIBODY HAVING A POLYMERIC DYE BOUND THERETO | ABBOTT LABORATORIES (US) | 1999-11-30 | — | — | US | disclosed |
| WO-1997028447-A1 | POLYMERIC FLUOROPHORES ENHANCED BY MOIETIES PROVIDING A HYDROPHOBIC AND CONFORMATIONALLY RESTRICTIVE MICROENVIRONMENT | ABBOTT LABORATORIES (US) | 1997-08-07 | — | — | WO | disclosed |