⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1701814 | 1.00 | — | — | |
| SCHEMBL167052 | 0.78 | ALDH1A1 (0.37) | — | |
| SCHEMBL30262989 | 0.78 | TSHR (0.41) | — | |
| SCHEMBL28069237 | 0.78 | TSHR (0.41) | — | |
| SCHEMBL33774 | 0.78 | TSHR (0.41) | — | |
| SCHEMBL18515739 | 0.75 | — | — | |
| SCHEMBL374340 | 0.75 | — | — | |
| SCHEMBL3743069 | 0.75 | — | — | |
| T-4-Aminocrotonic Acid (Taca) SCHEMBL29669578 | 0.75 | — | — | |
| T-4-Aminocrotonic Acid (Taca) SCHEMBL232135 | 0.75 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0039663-B1 | PROCESS FOR PREPARING CROSSLINKED SATURATED POLYMERS, AND THESE POLYMERS | CIBA-GEIGY AG (CH) | 1985-08-28 | — | — | EP | claimed |
| CN-119424423-A | 4-Aminobut-2-enamide derivatives and salts thereof | 大鹏药品工业株式会社 | 2025-02-14 | — | — | CN | disclosed |
| CN-117980309-A | Tricyclic fused pyrimidine compounds useful as HER2 inhibitors | 百时美施贵宝公司 | 2024-05-03 | — | — | CN | disclosed |
| US-20230023023-A1 | 4-AMINOBUT-2-ENAMIDE DERIVATIVES AND SALTS THEREOF | ASTEX THERAPEUTICS LIMITED (GB) | 2023-01-26 | — | — | US | disclosed |
| CN-115551500-A | 4-aminobut-2-enamide derivatives and salts thereof | 大鹏药品工业株式会社 | 2022-12-30 | — | — | CN | disclosed |
| CN-115551500-A | 4-aminobut-2-enamide derivatives and salts thereof | 大鹏药品工业株式会社 | 2022-12-30 | — | — | CN | disclosed |
| EP-4051266-A1 | 4-AMINOBUT-2-ENAMIDE DERIVATIVES AND SALTS THEREOF | Taiho Pharmaceutical Co., Ltd. (JP) | 2022-09-07 | — | — | EP | disclosed |
| WO-2021084765-A1 | 4-AMINOBUT-2-ENAMIDE DERIVATIVES AND SALTS THEREOF | TAIHO PHARMACEUTICAL CO., LTD (JP) | 2021-05-06 | — | — | WO | disclosed |
| WO-2021085653-A1 | 4-AMINOBUT-2-ENAMIDE DERIVATIVES AND SALTS THEREOF | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 2021-05-06 | — | — | WO | disclosed |
| WO-2020243457-A1 | COMPOUNDS AND THERAPEUTIC USES THEREOF | VIOGEN BIOSCIENCES, LLC (US) | 2020-12-03 | — | — | WO | disclosed |
| WO-2010118309-A2 | INHIBITORS OF STAT3 AND USES THEREOF | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2010-10-14 | — | — | WO | disclosed |
| WO-2003013740-A1 | 4- AND 5-AMINO-α, β UNSTATURATED ESTER SOLID SUPPORT TEMPLATES, METHOD OF PREPARATION AND FOR USING THE SAME | ADVANCED SYNTECH, LLC (US) | 2003-02-20 | — | — | WO | disclosed |
| EP-0457129-B1 | Process for the preparation of amine-terminated compounds | MILES INC (US) | 1995-01-18 | — | — | EP | disclosed |
| EP-0457129-A2 | Process for the preparation of amine-terminated compounds | MILES INC. (US) | 1991-11-21 | — | — | EP | disclosed |
| US-5066824-A | Polyhydroxy compound or polymer esterified with acetoacetic acid, then reacted with amine | MOBAY CORPORATION (US) | 1991-11-19 | — | — | US | disclosed |
| EP-0266989-B1 | DIHYDROPYRIDINE ANTI-ALLERGIC AND ANTI-INFLAMMATORY AGENTS | Pfizer Limited (GB) | 1990-07-04 | — | — | EP | disclosed |
| US-4788205-A | ANTAGONISTS OF PLATELET ACTIVATING FACTOR | PFIZER INC. (US) | 1988-11-29 | — | — | US | disclosed |
| EP-0288628-A1 | Process for producing 2-methyl-3-carbamido-quinoxaline-1, 4-di-n-oxides | Chisso Corporation (JP) | 1988-11-02 | — | — | EP | disclosed |
| EP-0258033-A2 | Dihydropyridine anti-allergic and anti-inflammatory agents | Pfizer Limited (GB) | 1988-03-02 | — | — | EP | disclosed |
| EP-0220653-A2 | 3-Aminocarbonyl-1,4-dihydropyridine-5-carboxylic acid compounds, process for preparation and use thereof, and pharmaceutical composition containing the same | Nippon Shoji Kabushiki Kaisha (JP) | 1987-05-06 | — | — | EP | disclosed |